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CATEGORIES:Foster Talks
SUMMARY:Physical aspects of collective cell migration - Dr
  
Alexandre 
Kabla\, 
Dept 
of 
Engineering\, Univ
  of 
Cambridge
DTSTART;TZID=Europe/London:20110217T160000
DTEND;TZID=Europe/London:20110217T170000
UID:TALK29198AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/29198
DESCRIPTION:A number of biological processes\, such as embryo 
 development\, cancer metastasis or wound healing\,
  rely on cells moving in concert. The mechanisms l
 eading to the emergence of group motion remain lar
 gely unexplored. Although biomolecular signalling 
 is known to be involved in most occurrences of col
 lective migration\, the role of physical and mecha
 nical interactions has been so far poorly addresse
 d. In this presentation\, a simple framework for c
 ell motility is implemented in-silico in order to 
 study the minimal requirements for the coordinatio
 n of a group of epithelial cells\, either as a spo
 ntaneously emerging behaviour\, or as a response t
 o "leader" cells. It appears that a key parameter\
 , essentially characterising the ratio between the
  cohesion of the tissue and the motile force of in
 dividual cells\, has the ability to control a wide
  spectrum of behaviours\, from the epithelial-mese
 nchymal transition to the onset of collective inva
 sion in cancer metastasis. This unified picture al
 lows us to reassess the role of biomolecular signa
 lling in a broader context and suggest a novel mec
 hanism for driving cell sorting in remodelling tis
 sues.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\
 , Downing Site
CONTACT:Christian Scheppach
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