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SUMMARY:Systems Vaccinology - Dr. Bali Pulendran\, Violetta L. Horton Prof
 essor at the Stanford University School of Medicine\, and Director of the 
 Institute for Immunology\, Transplantation and Infection\, and the Departm
 ents of Pathology and Microbiology & Immunology.
DTSTART:20250729T100000Z
DTEND:20250729T110000Z
UID:TALK234313@talks.cam.ac.uk
CONTACT:Ruth Paton
DESCRIPTION:This Cambridge Immunology Network Seminar will take place on T
 uesday 29 July 2025\, starting at 11:00am\, in the Ground Floor Lecture Th
 eatre\, Jeffrey Cheah Biomedical Centre (JCBC)\n\nSpeaker: Dr. Bali Pulend
 ran\, Violetta L. Horton Professor at the Stanford University School of Me
 dicine\, and Director of the Institute for Immunology\, Transplantation an
 d Infection\, Departments of Pathology and Microbiology & Immunology.\n\nT
 itle: Systems Vaccinology\n\nAbstract: Although the development of effecti
 ve vaccines has saved countless lives from infectious diseases\, the basic
  workings of the human immune system are complex and have required the dev
 elopment of animal models\, such as inbred mice\, to define mechanisms of 
 immunity. However\, past results are not necessarily a reliable guide to t
 he future\, and a notable limitation of animal models has been their failu
 re to accurately model some human diseases and their inability to predict 
 human immune responses in many cases. In the past decade there has been an
  explosion of new approaches and technologies to explore the human immune 
 system with unprecedented precision. Insights into the human immune respon
 se to vaccination\, cancers\, and viral infections such as COVID-19 have c
 ome from high-throughput “omics” technologies that measure the behavio
 r of genes\, mRNA\, proteins\, metabolites\, cells\, and epigenetic modifi
 cations\, coupled with computational approaches. I will discuss how these 
 “Systems Vaccinology” approaches are advancing our mechanistic underst
 anding of the human system and its response to vaccines and infections and
  facilitating the development of vaccines against HIV\, malaria and other 
 infectious diseases.\n\nShort Bio:\nBali Pulendran is the Violetta L. Hort
 on Professor at the Stanford University School of Medicine\, and Director 
 of the Institute for Immunology\, Transplantation\, and Infection\, at Sta
 nford University. He received his undergraduate degree from Cambridge Univ
 ersity\, and his Ph.D.\, from the Walter & Eliza Hall Institute in Melbour
 ne\, Australia\, under the supervision of Sir Gustav Nossal. He then did h
 is post-doctoral work at Immunex Corporation in Seattle. \n\nDr. Pulendran
  has had a transformative impact on human immunology and vaccinology by pi
 oneering the use of systems approaches to probe immunity to vaccination an
 d infection in humans. In addition\, Dr. Pulendran discovered that dendrit
 ic cells\, one of the key cell types orchestrating the immune response\, c
 onsist of multiple subtypes\, which are functionally distinct. He also dis
 covered the mechanisms by which microbial stimuli program DCs to modulate 
 T-helper responses and helped establish Flt3-Ligand as the key growth fact
 or for DCs in vivo. These groundbreaking findings helped define major para
 digms in innate immunity. \n\nDr. Pulendran’s research is published in f
 ront line journals such as Nature\, Science\, Cell\, Nature Medicine\, and
  Nature Immunology. Dr. Pulendran serves on many advisory boards including
  that of Keystone Symposia and on the External Immunology Network of GSK. 
 He is a fellow of the American Association for the Advancement of Science 
 and the recipient of several honors and awards\, including two concurrent 
 MERIT awards from the NIH\, the AAI Ralph Steinman Award for Human Immunol
 ogy\, the Albert Levy Prize\, the ViE Award for the Best Research Team at 
 the World Vaccine Congress\, and  is listed on Thomson Reuter’s list of 
 Highly Cited Researchers\, which recognizes the world's most influential r
 esearchers of the past decade\, demonstrated by the production of multiple
  highly-cited papers that rank in the top 1% by citations.\n\nHost: Teichm
 ann Research Group\, Cambridge Stem Cell Institute & Department of Medicin
 e
LOCATION: Lecture Theatre\, Jeffrey Cheah Biomedical Centre\, Cambridge Bi
 omedical Campus
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