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CATEGORIES:Genetics Seminar 
SUMMARY:Remodelling the septin cytoskeleton for cytokinesi
 s in budding yeast - Dr Simonetta Piatti from Cent
 re de Recherche en Biologie Cellulaire de Montpell
 ier
DTSTART;TZID=Europe/London:20260312T140000
DTEND;TZID=Europe/London:20260312T150000
UID:TALK231142AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/231142
DESCRIPTION:Septins are conserved cytoskeletal proteins essent
 ial for processes such as cell division\, spermato
 genesis\, neuronal morphogenesis\, ciliogenesis\, 
 infection\, and cell migration. Their dysfunction 
 is linked to neurodegeneration\, infertility\, and
  cancer.\nSeptins polymerize into filaments and hi
 gher-order structures like rings and arcs\, which 
 are crucial for their function. A classic example 
 is the septin collar in budding yeast—an hourglass
 -shaped structure at the bud neck that persists th
 rough most of the cell cycle and is essential for 
 cytokinesis. It recruits numerous cytokinetic prot
 eins\, including components of the contractile act
 omyosin ring.\nJust before cytokinesis\, the yeast
  septin collar undergoes a major remodelling into 
 a double ring that sandwiches the actomyosin ring.
  We recently showed that this remodelling is requi
 red for actomyosin ring constriction and successfu
 l cytokinesis.\nIn this seminar\, I will discuss o
 ur work uncovering the molecular basis of septin r
 ing reorganisation in budding yeast. Interestingly
 \, similar septin remodelling has been observed in
  other fungi and in mammalian cells\, suggesting a
 n evolutionarily conserved process.\n
LOCATION:Biffen Lecture theatre and Zoom
CONTACT:Caroline Newnham
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