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DTSTART:19700329T010000
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CATEGORIES:Biochemistry Seminar Series - External Speakers
SUMMARY:Post-transcriptional regulations via small molecul
 es targeting RNA-binding proteins - Peng Wu
DTSTART;TZID=Europe/London:20250603T120000
DTEND;TZID=Europe/London:20250603T130000
UID:TALK226471AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/226471
DESCRIPTION:Dysregulation of protein–RNA interactions has been
  associated with various human diseases\, while fe
 w chemical matters targeting RNA-binding proteins 
 (RBPs) or RNAs are available. In this context\, th
 e Wu group investigates small-molecule-based strat
 egies targeting protein–RNA interaction and RNA-bi
 nding proteins to offer new chemotypes for the mod
 ulation of post-transcriptional regulations. The o
 verall goal is to address the unmet need to invest
 igate the pervasive yet understudied protein–RNA i
 nteractions and the associated biological regulato
 ry network\, as well as to answer the daunting que
 stion regarding the tractability of targeting RNA-
 binding proteins with new chemical modalities of t
 herapeutic potential. For example\, the group has 
 successfully established discovery pipelines for t
 he identification of small molecules that targeted
  disease-associated RNA-binding proteins involved 
 in RNA biogenesis (LIN28)\, RNA cleavage and decay
  (RNase L and IRE1)\, and RNA modification (METTL1
 6 and YTHDF2). Furthermore\, proximity-inducing bi
 functional molecules were studied in the group as 
 chemical probes to illustrate the regulatory mecha
 nism of the complex protein–RNA network or as pote
 ntial drug candidates for the development of small
 -molecule-based therapeutics with new mechanisms o
 f action. The talk will exemplify recent small-mol
 ecule discovery efforts from the group targeting s
 uch RNA-binding proteins.
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Te
 nnis Court Road
CONTACT:
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