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CATEGORIES:Cambridge Immunology Network Seminar Series
SUMMARY:Endurance of germinal centers in absence of Tfh ce
 lls - Dr Michelle Linterman\, Babraham Institute\,
  Cambridge
DTSTART;TZID=Europe/London:20241024T160000
DTEND;TZID=Europe/London:20241024T170000
UID:TALK221350AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/221350
DESCRIPTION:This Cambridge Immunology and Medicine Seminar wil
 l take place on Thursday 24 October 2024\, startin
 g at 4:00pm\, in the Theo Chalmers Lecture Theatre
  (LT2)\, School of Clinical Medicine.\n\nSpeaker: 
 Dr Michelle Linterman\, Babraham Institute\, Cambr
 idge\n\nTitle: Endurance of germinal centers in ab
 sence of Tfh cells\n\nAbstract: \nT follicular hel
 per cells (Tfh) are essential for the formation of
  germinal center (GC) reactions\, and positive sel
 ection of GC B cells. Interrogating their role in 
 an ongoing GC reaction has been challenging as few
  in vivo models manipulate Tfh cells in establishe
 d GCs. Here\, we use an Il21 fate mapping (Il21-fm
 ) mouse to genetically target Tfh cells enabling t
 heir deletion at the peak of the GC reaction. We s
 how that although Tfh cells are required for drivi
 ng ongoing GC B cell proliferation\, an establishe
 d GC can withstand their temporary absence. The re
 generative capacity of Tfh cells results in rejuve
 nation of the GC and return of affinity maturation
 . This recovery suggests the GC has evolved to cop
 e with environmental stresses such as co-infection
 -associated immune-suppression\, ensuring the gene
 ration of enduring humoral immunity.\n\n\nHost: Ge
 org Petkau\, Babraham Institute\, Cambridge\n\nRef
 reshments will be available before the seminar.
LOCATION:Theo Chalmers Lecture Theatre (LT2)\,  School of C
 linical Medicine\, Cambridge Biomedical Campus
CONTACT:Ruth Paton
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