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CATEGORIES:Electrical Engineering
SUMMARY:Building advanced neuromuscular organoids to study
  human development and disease - Mina Gouti. Max-D
 elbruck Centre for Molecular Medicine
DTSTART;TZID=Europe/London:20240906T160000
DTEND;TZID=Europe/London:20240906T170000
UID:TALK219847AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/219847
DESCRIPTION:Locomotion results from the interaction between mu
 scles and the nervous system. Dysfunction of such 
 cells results in deadly diseases such as spinal mu
 scular atrophy (SMA) and amyotrophic lateral scler
 osis (ALS). Neuromuscular diseases often show regi
 onal selectivity but the underlying reasons remain
  obscure due to the lack of a suitable human model
  system. We have recently used human pluripotent s
 tem cell derived axial stem cells\, the building b
 locks of the posterior body\, to simultaneously ge
 nerate spinal cord neurons and skeletal muscle cel
 ls that self-organize in 3D to generate neuromuscu
 lar organoids (NMOs). NMOs contain functional neur
 omuscular junctions supported by terminal Schwann 
 cells. They contract and develop central pattern g
 enerator-like neuronal circuits (Martins et al\, C
 ell Stem Cell\, 2020). We are currently applying N
 MOs to study the early development of the human ne
 uromuscular system and to model neuromuscular dise
 ases. This approach promises to uncover the sequen
 ce of events and provide greater insight into the 
 mechanisms that lead to specific diseases by tackl
 ing previously inaccessible features of neuromuscu
 lar junction biology.\n
LOCATION:West Hub\, West 2
CONTACT:Kirsty Shepherd
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