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CATEGORIES:Morphogenesis Seminar Series
SUMMARY:Echinoderm embryos to model epithelial morphogenes
 is: from cell biology to evo-devo - Vanessa Barone
 \, Hopkins Marine Station\, Biology Department\, S
 tanford University
DTSTART;TZID=Europe/London:20240205T143000
DTEND;TZID=Europe/London:20240205T153000
UID:TALK210901AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/210901
DESCRIPTION:*Abstract*: Embryos of many echinoderm species dev
 elop freely in sea water with a fertilisation enve
 lope as the only protection from environmental ins
 ults. In the sea star Patiria miniata the fertilis
 ation envelope not only protects\, but also helps 
 shape the early embryo\, as the embryonic cells fo
 rm a blastula by lining the inner surface of the e
 nvelope. This raises the possibility that the spat
 ial constraints imposed by the envelope may influe
 nce epithelial morphogenesis\, e.g. compaction\, c
 ell density and cell connectivity.\n\nWe used live
 -imaging of the sea star embryo coupled with deep 
 learning-based segmentation\, to dissect the relat
 ive contributions of cell density\, tissue compact
 ion\, and cell proliferation on epithelial archite
 cture. We found that the 3D connectivity of cells 
 within the tissue changes over time as epithelial 
 compaction and cell density increase. Importantly\
 , these changes in 3D packing are due to the combi
 ned effects of cell division within the embryo and
  of the spatial constraints acting on the embryos.
  \n\nThese results raise interesting hypotheses co
 ncerning the role of protective structures\, such 
 as the fertilisation envelope\, in key aspects of 
 embryonic development and its evolution. \n\nJoin 
 Zoom Meeting \n\n\nhttps://us06web.zoom.us/j/82089
 026611?pwd=L2FyclJFL2lYR0J3SFBDbHQyUFp6UT09 \n\n  
 \n\nMeeting ID: 820 8902 6611 \n\nPasscode: 038347
  \n\n  \n
LOCATION:Online
CONTACT:Jia CHEN
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