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SUMMARY:Exploring novel (bio)molecular spaces by design – a dialogue bet
 ween representation and generation - Professor Bruno Correia - Laboratory 
 of Protein Design and Immunoengineering\, EPFL Swiss Federal Institute of 
 Technology\, Lausanne.
DTSTART:20240501T140500Z
DTEND:20240501T145500Z
UID:TALK210466@talks.cam.ac.uk
CONTACT:Ben Karniely
DESCRIPTION:The machine learning tool box has revolutionized our ability t
 o design novel molecular entities (e.g. proteins) well beyond what the nat
 ural repertoire has explored. Despite the incredible advances\, the de nov
 o generation of functional molecules in biological concepts remains an inc
 redible challenge.\n\nIn this talk I will present some of the efforts in o
 ur group in designing both proteins and small molecules. Particularly emph
 asizing different modalities of molecular representation and the interplay
  with generative ML to facilitate the exploration of unimaginably large sp
 aces of possibilities. Importantly\, many ML-based approaches for molecula
 r design fall short in terms of generalization and sampling off the learne
 d distribution\, I will present some ideas on how representation can help 
 to overcome some of these limitations. \n\nFinally\, I will present some o
 f the approaches developed in our group to embed function into the designe
 r proteins and how we are suing these components in cellular systems to co
 ntrol the output of these complex biological devices.    \n\n\nLink to joi
 n virtually: https://cam-ac-uk.zoom.us/j/81322468305\n\nA recording of thi
 s talk is available at the following link: https://www.cl.cam.ac.uk/semina
 rs/wednesday/video/
LOCATION:Lecture Theatre 1\, Computer Laboratory\, William Gates Building
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