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CATEGORIES:Cambridge Cardiovascular Seminar Series
SUMMARY:Young at heart: new strategies for accelerating re
 generation - Professor Nadia Rosenthal The Jackson
  Laboratory\, Bar Harbor Maine US\, National Heart
  and Lung Institute\, Imperial College London UK
DTSTART;TZID=Europe/London:20231017T163000
DTEND;TZID=Europe/London:20231017T173000
UID:TALK207436AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/207436
DESCRIPTION:What lies behind the remarkable potential of the b
 ody to rebuild itself and why aren’t humans better
  at it? The limited restorative capacity of some t
 issues has been attributed to persistent inflammat
 ion with increasing age. Our approach has been to 
 tinker with immune mechanisms at work in the mamma
 lian response to damage\, disease and infection\, 
 compared to other highly regenerative animals. Usi
 ng combinations of genetic manipulation and pharma
 cological blockades\, we have shown how modifying 
 the profile of immune cell infiltration can facili
 tate or prevent regeneration of heart and other ti
 ssues in mouse and axolotl\, an efficiently regene
 rating member of the urodele amphibian family\, de
 pendent on distinct differences in immune composit
 ion and response between species. Analysis of tiss
 ue regeneration amongst diverse mouse populations 
 has also uncovered surprising variation that mimic
 s the broad spectrum of sterile and infectious imm
 une response and reparative trajectories in human 
 patients. The diverse regenerative capacity of adu
 lt mammalian organs is further reflected in their 
 cell composition and transcriptomic profiles\, hig
 hlighting the potential for more genetically preci
 se\, tissue-specific treatments. These studies sup
 port the feasibility of intervening with our own i
 ncomplete response to injury\, infection or diseas
 e as we age\, reducing the impediments to effectiv
 e regeneration and providing new targets for clini
 cal intervention.
LOCATION: Heart and Lung Institute\, Cambridge Biomedical C
 ampus
CONTACT:Denise Hatherly
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