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CATEGORIES:Chemical Engineering and Biotechnology
SUMMARY:Bigger Picture Talks - Can You Hear the Shape of a
  Crystal?  - Professor Tim Korter\, Syracuse Unive
 rsity
DTSTART;TZID=Europe/London:20231018T133000
DTEND;TZID=Europe/London:20231018T143000
UID:TALK207433AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/207433
DESCRIPTION:Please join us at the Department of Chemical Engin
 eering and Biotechnology to hear Professor Tim Kor
 ter\, Syracuse University present his talk: Can Yo
 u Hear the Shape of a Crystal? Terahertz Vibration
 al Spectroscopy of Challenging Pharmaceutical Crys
 tals\n\nSolubility is a property of great interest
  in the pharmaceutical industry where solid-state 
 drug formulations must maintain proper oral availa
 bility to be effective. The crystal structures of 
 pharmaceuticals are the key to understanding and e
 ngineering enhanced solubilities. However\, numero
 us drug molecules have unknown solid-state structu
 res and new approaches are needed to address this.
  In this work\, terahertz vibrational spectroscopy
  is used to measure the unique low-frequency vibra
 tions of molecular crystals. Material-specific ter
 ahertz spectral signatures arise from the packing 
 arrangements of the crystal components. The terahe
 rtz data are then used in partnership with quantum
  mechanical crystal structure prediction methods t
 o achieve complete three-dimensional structural in
 formation about these challenging pharmaceutical s
 olids. An overview of the approach will be describ
 ed using molecular examples ranging from simple ma
 leic acid to the more complex glibenclamide that h
 ighlight terahertz spectroscopy as an orthogonal m
 eans for solving pharmaceutical crystal structures
 .
LOCATION:Lecture Theatre 1\, Department of Chemical Enginee
 ring  and Biotechnology\, New Museums Site
CONTACT:
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