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CATEGORIES:Isaac Newton Institute Seminar Series
SUMMARY:Polymer Assisted Condensation: How polymers can co
 ntrol and localize liquid-liquid phase separation 
 - Jens-Uwe  Sommer (Leibniz Institute of Polymer R
 esearch Dresden)
DTSTART;TZID=Europe/London:20231013T135000
DTEND;TZID=Europe/London:20231013T143000
UID:TALK204934AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/204934
DESCRIPTION:Jens-Uwe Sommer1\,2\,3\, Holger Merlitz1 and Helmu
 t Schie&szlig\;el2\,3\n&nbsp\;\n1Leibniz Institute
  of Polymer Research Dresden\, Germany2Institute f
 or Theoretical Physics\, TU Dresden\, Germany3Clus
 ter of Excellence &ldquo\;Physics of Life&rdquo\; 
 TU Dresden\, Germany\n&nbsp\;\n&nbsp\;\nLiquid-liq
 uid phase separation of proteins is increasingly r
 ecognized as a fundamental concept to understand b
 iological functions. Biomolecular condensates are 
 formed at specific places in the cell\, but what c
 ontrols their size and life-time\, and by which me
 chanisms different condensates interact or exchang
 e material (and possibly information) with each ot
 her as well as with the environment is still large
 ly unexplored. We introduce polymer-assisted conde
 nsation (PAC) which can explain the formation of l
 ocalized and size-controlled condensates using con
 cepts from polymer physics and phase separation th
 eory. Our work\, consisting of mean-field theory a
 nd simulations\, highlights the role of meta-stabl
 e states of multi-component solutions near the mis
 cibility gap which can be switched into condensed 
 states triggered by a weak attractive interaction 
 with a polymer. A significant change in interactio
 n strength between proteins and polymer leaves the
  properties of the polymer-assisted condensate nea
 rly invariant\, and fluctuations in the concentrat
 ion of the proteins outside the condensate are buf
 fered which makes polymer-assisted condensates to 
 be robust against variation of environmental facto
 rs. As an example we consider the case of hetero-c
 hromatin. Here\, the features of PAC provide a rat
 ional basis to explain preservation of epigenetic 
 information during the cell cycle.\n&nbsp\;\nJ.-U.
  Sommer\, H. Merlitz\, H. Schie&szlig\;el\nPolymer
 -Assisted Condensation: A Mechanism for Hetero-Chr
 omatin Formation and Epigenetic Memory\nMacromolec
 ules 55\, 4841 (2022)
LOCATION:Seminar Room 1\, Newton Institute
CONTACT:
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