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DTSTART:19700329T010000
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CATEGORIES:Isaac Newton Institute Seminar Series
SUMMARY:Physical principles of controlling condensates by 
 reactions - David Zwicker (Max Planck Institute fo
 r Dynamics and Self Organisation)
DTSTART;TZID=Europe/London:20231012T102000
DTEND;TZID=Europe/London:20231012T110000
UID:TALK204904AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/204904
DESCRIPTION:Condensates spatially partition the complex cellul
 ar interior using genetically encoded interactions
  between various biomolecules. Yet\, to fulfill co
 untless cellular functions\, condensates also need
  to form at the right time\, at the right position
 \, and with the right size. I will demonstrate how
  driven chemical reactions enable such control. Ba
 sed on thermodynamic constraints\, I will show tha
 t reactions involving the droplet material must be
  driven out of equilibrium\, e.g.\, by consuming A
 TP. Then\, enzymes concentrated inside or outside 
 the droplet can create compositional gradients tha
 t affect droplet nucleation\, shape\, and position
 . Interestingly\, the length scale associated with
  this reaction-diffusion system governs droplet si
 ze and spacing\, akin to Turing patterns. I will m
 ake this analogy more precise by discussing Turing
  patterns with physical interactions\, i.e.\, non-
 ideal diffusion. In summary\, I will discuss the i
 ntertwined physics of non-ideal diffusion and chem
 ical reactions\, which is relevant beyond Biology.
LOCATION:Seminar Room 1\, Newton Institute
CONTACT:
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