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DTSTART:19700329T010000
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CATEGORIES:Microglia webinar series
SUMMARY:Microglia and astrocyte involvement in synapse los
 s in Alzheimer’s disease - Prof. Tara Spires-Jones
 . University of Edinburgh\, UK
DTSTART;TZID=Europe/London:20230502T160000
DTEND;TZID=Europe/London:20230502T170000
UID:TALK183734AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/183734
DESCRIPTION:Synapse loss is the strongest pathological correla
 te of cognitive decline in Alzheimer’s disease (AD
 ) and genetic data strongly implicate both amyloid
  beta and changes in microglia in disease pathogen
 esis. In this talk\, Prof Spires-Jones will talk a
 bout her work showing that (1) Amyloid beta (Ab) a
 ccumulates in synapses and contributes to synapse 
 loss\, (2) APOE4 and CLU risk genes associated wit
 h synapse loss\, (3) Astrocytes and microglia inge
 st synapses in human AD brain\, and (4) Blocking M
 FGE8 binding integrin receptors reduces human syna
 pse phagocytosis by microglia and astrocytes.\n
LOCATION:https://zoom.us/j/94128601767?pwd=UklLN2h5ZGNVL3BM
 YVNqdXh3djRXZz09
CONTACT:Timothy Birkle
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