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CATEGORIES:Isaac Newton Institute Seminar Series
SUMMARY:Contributed Talk: Eco-evolutionary dynamics of coo
 perative antimicrobial resistance - Lluís Hernánde
 z-Navarro (University of Leeds)
DTSTART;TZID=Europe/London:20221011T145000
DTEND;TZID=Europe/London:20221011T151000
UID:TALK179336AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/179336
DESCRIPTION:Microorganisms live in ecologically dynamic enviro
 nments that inevitably fluctuate between mild and 
 harsh conditions. Critically\, the latter gives ri
 se to higher demographic noise and random extincti
 ons that govern evolutionary dynamics\, which in t
 urn might shape the environmental conditions throu
 gh large-scale feedback loops. Although the indepe
 ndent contributions of environmental variability (
 EV) and demographic fluctuations (DF) have been ex
 tensively studied\, the emerging&nbsp\;`eco-evo dy
 namics'&nbsp\;resulting from the EV and DF joint i
 nterplay remains largely unknown due to its challe
 nging complexity and interdisciplinary nature. Thi
 s poses an open problem that is crucial for many r
 elevant\, real world living systems.\nIn this stud
 y we focus on the eco-evo dynamics in the paramoun
 t case of AntiMicrobial Resistance (AMR)\, which c
 urrently causes 7*10^5 deaths every year\, and is 
 estimated to become the cause of 10 million yearly
  deaths by 2050. AMR is typically characterized by
  cooperative behaviour: a mutant strain generates 
 a Public Good (PG\; e.g.\, extracellular enzyme) a
 t some metabolic cost (reduced birth rate) and the
  PG inhibits the antimicrobial drug for all the po
 pulation (antimicrobial-independent rates for all 
 strains). Furthermore\, PG is typically shared onl
 y when the number of cooperators Nc overcomes a gi
 ven threshold N_c>N_th. Below N_th the Good is hel
 d private\, within cooperators' intracellular medi
 um\, and non-PG-producers become vulnerable to ant
 imicrobial drugs.We will thus discuss the AMR eco-
 evo dynamics of a well-mixed\, finite microbial po
 pulation of fluctuating size composed of a coopera
 tive\, PG-producer strain and a `free-rider'\, def
 ector strain. The former has a constant but lower 
 birth rate\, while the latter has a higher birth r
 ate that drastically reduces in the presence of an
 timicrobial drugs\, unless the fraction of coopera
 tors is high and PG is shared. The resulting eco-e
 vo dynamics\, arising from the direct coupling bet
 ween the evolutionary state (level of cooperation)
  and the environmental condition (active/inhibited
  antimicrobial drug for defectors)\, and that enha
 nces species coexistence\, will be presented. And\
 , finally\, we will discuss the impact of a more r
 ealistic time-dependent\, fluctuating environment.
LOCATION:Seminar Room 1\, Newton Institute
CONTACT:
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