BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Connecting Sensory Perception to Longevity in C. elegans - Dr Rebe
 cca Taylor\, MRC Laboratory of Molecular Biology\, Cambridge
DTSTART:20221124T140000Z
DTEND:20221124T150000Z
UID:TALK177062@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Detecting and responding to environmental stress is crucial to
  the survival of organisms. My lab studies the ways in which stress detect
 ion by the nervous system leads to the activation of organism-wide defence
  mechanisms that can slow down the ageing process. In particular\, we are 
 interested in the unfolded protein response of the endoplasmic reticulum (
 UPRER)\, and its activation in downstream tissues following signalling by 
 neurons. Through studying the transcriptome of different cell types in C. 
 elegans following genetic activation of the UPRER\, we have uncovered mech
 anisms by which UPRER activation in the nervous system triggers the sendin
 g of UPRER-activating signals to the intestinal cells of the animal\, and 
 have also revealed the ability of neuronal stress response activation to a
 lter the behavior of the worm in ways that are appropriate to stressful en
 vironments. In addition\, we have identified a novel ability of intestinal
  UPRER activation to enhance the acidity and activity of lysosomes\, leadi
 ng to improved protein and metabolic homeostasis and resulting in delayed 
 ageing and extended longevity. Finally\, we have pinpointed specific envir
 onmental cues that trigger UPRER-activating neuronal signalling. Our analy
 ses have therefore revealed novel mechanisms by which multicellular organi
 sms orchestrate resilience in the face of stress\, utilizing neuronal sign
 aling systems to coordinate multiple responses across different tissues of
  the animal.\n\n
LOCATION:Zoom meeting
END:VEVENT
END:VCALENDAR