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CATEGORIES:Darwin College Science Seminars
SUMMARY:Functional redundancy of Drosophila melanogaster S
 oxB proteins in central nervous system development
  - Barbara Joo\, Department of Genetics
DTSTART;TZID=Europe/London:20211014T130000
DTEND;TZID=Europe/London:20211014T140000
UID:TALK161920AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/161920
DESCRIPTION:During neural development\, SoxB proteins are tran
 scriptions factors that play an important role in 
 the maintenance of stem-cell identity. One member 
 of this family\, Sox2 has been successfully used t
 o induce cells into a pluripotent state (iPSCs) an
 d is involved in different disorders promoting cel
 ls self-renewal. Interestingly\, SoxB proteins hav
 e shown pioneer and redundant activity even when n
 atural selection imposes evolutionary pressure to 
 prevent gene duplications. Moreover\, a high funct
 ional conservation and high levels of sequence sim
 ilarity\, allow us to assess functionality in vivo
  and at a chromatin level using Drosophila melanog
 aster as our model organism and its genes SoxN and
  Dichaete\, orthologs of mammalian and other verte
 brates SoxB genes
LOCATION:Richard King room\, Darwin College
CONTACT:Dr Tamsin Samuels
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