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CATEGORIES:Cambridge Society for the Application of Research 
 (CSAR)
SUMMARY:Tooth Regeneration and Repair: Dentistry in the 21
 st century - Professor Paul Sharpe\, King's Colleg
 e London\, Head of the Centre for Craniofacial &am
 p\; Regenerative Biology\, Dickinson Professor of 
 Craniofacial Biology.
DTSTART;TZID=Europe/London:20201130T193000
DTEND;TZID=Europe/London:20201130T210000
UID:TALK154537AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/154537
DESCRIPTION:Stem cells can be identified in the stroma (connec
 tive tissue) of most tissues and organs. These cel
 ls provide a source of cells that become activated
  upon tissue damage to generate differentiated cel
 l types that promote tissue repair. Specific targe
 ting of these resident stem cells has become a maj
 or goal for regenerative therapies.\n\nUsing the m
 ammalian tooth as an easily accessible model organ
 \, we have developed a novel drug treatment (ReDen
 t) that activates resident stem cells in the tooth
  pulp to differentiate into the specialised cell t
 ype (odontoblasts) that produce reparative dentine
 . ReDent thus promotes self-repair of teeth follow
 ing caries removal. ReDent is anticipated to be in
  clinical trials in the next 12 months. These same
  principles are also being applied to the developm
 ent of stem cell-based treatments for periodontal 
 disease.\n\nTeeth are currently replaced using den
 tal implants or prostheses (false teeth). The ulti
 mate goal of regenerative dentistry is to use bioe
 ngineering approaches to develop a method that all
 ows a complete new functional tooth to grow in the
  mouth. The basic proof-of-principle showing this 
 is possible was established several years ago. Our
  latest progress in this area will be presented an
 d the remaining obstacles discussed.
LOCATION:Location: Zoom. See CSAR emails for joining inform
 ation.
CONTACT:John Cook
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