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CATEGORIES:DAMTP BioLunch
SUMMARY:Navigation on the microscale - how cells can sense
  the direction of external gradients - Ulrich Dobr
 amysl (Cambridge)
DTSTART;TZID=Europe/London:20200227T130000
DTEND;TZID=Europe/London:20200227T140000
UID:TALK138934AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/138934
DESCRIPTION:In many biological processes\, in particular embry
 onic and brain development\, cells need to follow 
 chemical gradients to arrive at a precise location
 . To this end\, they need to be able to determine 
 the direction and position of sources releasing di
 ffusing molecular guidance cues from information g
 athered by receptor clusters located on the cell m
 embrane. I will talk about what we learned regardi
 ng the limits of direction sensing in different en
 vironments from developing an analytical model\, u
 sing an asymptotic approach in two and three dimen
 sions\, and an efficient numerical simulation proc
 edure to calculate the particle fluxes to receptor
 s. I will discuss how we quantify the uncertainty 
 associated with location triangulation and that th
 e number of receptors decreases the uncertainty su
 per-exponentially\, enabling position reconstructi
 on over large distances. Finally\, I will show sim
 ulations of cells navigating in chemicals gradient
  based on these findings.
LOCATION:MR11\, Centre for Mathematical Sciences\, Wilberfo
 rce Road\, Cambridge
CONTACT:George Fortune
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