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CATEGORIES:Computational and Systems Biology
SUMMARY:RNA editing in plant organelles: Correlation betwe
 en editing sites and protein three-dimensional str
 uctures - Kei Yura (Ochanomizu University\, Tokyo)
DTSTART;TZID=Europe/London:20080930T130000
DTEND;TZID=Europe/London:20080930T140000
UID:TALK13504AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/13504
DESCRIPTION:In plant organelles\, specific messenger RNAs (mRN
 As) are subjected to conversion editing\, a proces
 s that often converts the first or second nucleoti
 de of a codon and hence of the encoded amino acid.
  No systematic patterns in converted sites were fo
 und on mRNAs\, and the converted sites rarely enco
 ded residues located at the active sites of protei
 ns. The role and origin of RNA editing in plant or
 ganelles remain to be elucidated. Here we study th
 e relationship between amino acid residues encoded
  by edited codons and the structural characteristi
 cs of these residues within proteins. We find that
  the residues encoded by edited codons are signifi
 cantly biased toward involvement in helices and pr
 otein structural cores. The puzzling point of the 
 finding is that the editing occurs on mRNA and pro
 tein 3D structures cannot play roles in the editin
 g processes. We propose the cause of the observed 
 correlation based on the evolution of land plants.
 \n\n
LOCATION:Lecture Theatre\, Department of Biochemistry\, Hop
 kins Building (old building)
CONTACT:Gos Micklem
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