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CATEGORIES:Department of Psychiatry &amp\; CPFT Thursday Lunc
 htime Seminar Series
SUMMARY:Ageing and dementia risk-related brain differences
  in the cognitively healthy: Evidence from multi-m
 odal MRI - Dr Claudia Metzler-Baddeley\, Senior Le
 cturer in Cognitive Neuroscience\, Cardiff Univers
 ity
DTSTART;TZID=Europe/London:20190912T123000
DTEND;TZID=Europe/London:20190912T133000
UID:TALK128269AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/128269
DESCRIPTION:As the global population is ageing\, the number of
  older people affected by conditions leading to de
 mentia such as Alzheimer’s disease (AD) is increas
 ing. As AD pathology is thought to accumulate over
  many years before the onset of cognitive impairme
 nts\, it may be possible to identify early warning
  signs associated with dementia risk so that asymp
 tomatic individuals at heightened risk can be stra
 tified into future clinical trials for novel preve
 ntative therapeutics. \nThe objective of the Cardi
 ff Ageing and Risk of Dementia Study (CARDS) (Metz
 ler-Baddeley et al. 2019a\,b) is to investigate th
 e impact of ageing and genetic and lifestyle risk 
 factors\, i.e. APOE4 genotype\, Family History (FH
 ) of dementia and central obesity\, on the brain a
 nd cognition in asymptomatic individuals. This was
  done in 166 cognitively healthy adults (38-71 yea
 rs of age) using non-invasive\, multi-parametric m
 agnetic resonance imaging (MRI). More specifically
 \, multi-component diffusion-based Neurite Orienta
 tion Density and Dispersion Imaging (NODDI) (Zhang
  et al 2012) was employed to gain metrics of neuri
 te microstructure (apparent neurite density\, orie
 ntation dispersion\, and free water tissue content
 ) and quantitative Magnetization Transfer (qMT) (S
 led 2018) and T1-relaxometry were used to gain met
 rics that are sensitive to myelin and inflammation
  [macromolecular proton fraction (MPF)\, forward e
 xchange rate kf\, R1). Ageing was associated with 
 a reduction of MPF\, kf\, and R1 and increases in 
 free water signal and orientation dispersion in wh
 ite and grey matter but no differences in apparent
  axon density. Furthermore\, synergistic effects o
 f FH\, APOE and Waist Hip Ratio were observed in w
 hite and grey matter MPF and in grey matter kf. Th
 ese results are consistent with neuropathological 
 evidence of age-related loss of myelin rather than
  axons. They also suggest that genetic and lifesty
 le risk factors adversely impact myelination. Thes
 e results will be discussed in light of a glia mod
 el of ageing and neurodegeneration (Bartzokis 2011
 ).
LOCATION:Seminar Room\, Herchel Smith Building\, Forvie Sit
 e.
CONTACT:Dr Muzaffer Kaser
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