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SUMMARY:Creating predictable gene knock-outs at scale with CRISPR/Cas9 - D
 r. Luca Crepaldi (Sanger) & Dr. Felicity Allen (Sanger)
DTSTART:20190306T183000Z
DTEND:20190306T200000Z
UID:TALK120949@talks.cam.ac.uk
CONTACT:Postdoc Masterclass
DESCRIPTION:CRISPR/Cas9\, a recently discovered DNA editing system\, is re
 volutionising biological research across\nmedicine\, agriculture and funda
 mental cell biology. It is employed to disable a selected gene to test\nwh
 ether this affects a particular cell function\, such as development or can
 cerous growth. Large-scale\nexperimental designs allow gene inactivation t
 o be carried out in pools of human or other eukaryotic\ncell lines\, such 
 that each and every gene is tested simultaneously\, in a comprehensive\, u
 nbiased\nfashion.\nThe first speaker will:\n• Give an introduction to CR
 ISPR/Cas9 and how it works\n• Explain how CRISPR/Cas9 can be used at sca
 le to screen for genes relevant to a biological function\nThe second speak
 er will:\n• Describe research examining and predicting the precise DNA m
 utations induced by CRISPR/Cas9\n• Outline how this can be used to produ
 ce better gene knock-outs and effective genetic screens
LOCATION: Postdoc Centre\, Biomedical Campus\, Bay 13\, Hills Road\, Cambr
 idge CB2 0SP
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