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CATEGORIES:Biophysical Seminars
SUMMARY:Recent progress in electron cryomicroscopy - Richa
 rd Henderson\, MRC Laboratory of Molecular Biology
DTSTART;TZID=Europe/London:20190403T103000
DTEND;TZID=Europe/London:20190403T113000
UID:TALK118981AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/118981
DESCRIPTION:In the last few years\, single particle electron c
 ryomicroscopy (cryoEM) \nhas experienced a quantum
  leap in its capability\, due to improved \nelectr
 on microscopes\, better detectors and better softw
 are\, and this is \nrevolutionising structural bio
 logy. Using the technique invented by \nJacques Du
 bochet and his colleagues\, a thin film containing
  a suspension of the macromolecules of interest is
  plunge-frozen into liquid ethane at liquid nitrog
 en temperature\, creating a frozen sample in which
  \nindividual images of the structures can be seen
  in many different \norientations. Subsequent comp
 uter-based image analysis is then used to \ndeterm
 ine the three-dimensional structure\, frequently a
 t near-atomic \nresolution. I will describe some r
 ecent results and discuss remaining \nbarriers to 
 progress. CryoEM is already a very powerful method
 \, but \nthere are still many improvements that ca
 n be made before the approach \nreaches its theore
 tical limits.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lec
 ture theatre
CONTACT:Gabriella Heller
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