COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring. |
University of Cambridge > Talks.cam > Isaac Newton Institute Seminar Series > Equilibrium distributions of simple biochemical reaction systems for time-scale separation in stochastic reaction networks
Equilibrium distributions of simple biochemical reaction systems for time-scale separation in stochastic reaction networksAdd to your list(s) Download to your calendar using vCal
If you have a question about this talk, please contact INI IT. This talk has been canceled/deleted Many biochemical reaction networks are inherently multiscale in time and in the counts of participating molecular species. A standard technique to treat different time scales in the stochastic kinetics framework is averaging or quasi-steady-state analysis: it is assumed that the fast dynamics reaches its equilibrium (stationary) distribution on a time scale where the slowly varying molecular counts are unlikely to have changed. We derive analytic equilibrium distributions for various simple biochemical systems, such as enzymatic reactions and gene regulation models. These can be directly inserted into simulations of the slow time-scale dynamics. They also provide insight into the stimulus–response of these systems. An important model for which we derive the analytic equilibrium distribution is the binding of dimer transcription factors (TFs) that first have to form from monomers. This gene regulatory mechanism is compared to the cases of the binding of simple monomer TFs to one gene or to multiple copies of a gene, and to the cases of the cooperative binding of two or multiple TFs to a gene. The results apply equally to ligands binding to enzyme molecules. This talk is part of the Isaac Newton Institute Seminar Series series. This talk is included in these lists:This talk is not included in any other list Note that ex-directory lists are not shown. |
Other listsClimate week Seminar Travel and Expeditions Von Hügel Institute events Sustainable Development: 11th Distinguished Lecture Series 2013 Meeting the Challenge of Healthy Ageing in the 21st CenturyOther talksDeveloping an optimisation algorithm to supervise active learning in drug discovery Magnetic microscopy of meteorites: probing the magnetic state of the early solar system National crises, viewed in the light of personal crises CANCELLED-Open tools in Marchantia for plant bioengineering work and as a platform for elucidating morphogenesis Making Refuge: Issam Kourbaj |