Imaging the virosphere: protein architecture for virus assembly and host cell entry

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• Professor Peter Rosenthal
• Tuesday 02 December 2025, 18:00-19:00
• Pfizer Lecture Theatre, Department of Chemistry, Lensfield Road.

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Viruses have evolved mechanisms to transfer their genes into host cells in order to make copies of themselves and infect other cells. A solution used by many pathogenic viruses is to assemble and leave the cell by budding through and wrapping itself in the host membrane. When infecting the cell, these lipid-enveloped viruses attach to the surface of cells and then enter by fusing the virus membrane with host membranes. Focussing on viruses such as influenza virus, coronaviruses, and retroviruses, this presentation describes the application of cryogenic electron microscopy (cryo-EM) to understand the protein architecture used by these viruses to self-assemble and to fuse with target cells.

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