Neural basis of decision making

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• Guillaume Hennequin ( University of Cambridge); Robert Crossen
• Tuesday 11 November 2025, 13:15-12:45
• CBL Seminar Room, Engineering Department, 4th floor Baker building.

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We will present two recent studies from the Brody lab exploring the neural dynamics underlying perceptual decision-making and commitment. Luo et al. (2025) used large-scale neural recordings and data-driven modelling to reveal that during auditory evidence accumulation, cortical and striatal population activity transitions between two distinct dynamical regimes—an early, input-driven phase and a later, autonomous phase marking decision commitment. Building on this, Bondy et al. (2025) examined brain-wide recordings across up to twenty regions, showing that decision signals and inferred commitment times co-fluctuate across the brain along a single dominant dimension, originating in a frontal–striatal subnetwork and propagating globally. Together, these studies provide a compelling multi-scale view of how local and distributed neural dynamics give rise to coherent, brain-wide decision processes.

References: Luo, T. Z., Kim, T. D., Gupta, D., Bondy, A. G., Kopec, C. D., Elliott, V. A., DePasquale, B. & Brody, C. D. (2025). Transitions in dynamical regime and neural mode during perceptual decisions. Nature, 646, 1156–1166. https://www.nature.com/articles/s41586-025-09528-4 Bondy, A. G., Charlton, J. A., Luo, T. Z., Kopec, C. D., Stagnaro, W. M., Venditto, S. J. C., Lynch, L., Janarthanan, S., Oline, S. N., Harris, T. D. & Brody, C. D. (2025). Brain-wide coordination of decision formation and commitment. bioRxiv. https://www.biorxiv.org/content/10.1101/2024.08.21.609044v5

This talk is part of the Computational Neuroscience series.

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