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Cambridge Fly Club

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  • UserMegan Oliva, Department of Genetics and Alex Bates, MRC Laboratory of Molecular Biology & University of Cambridge
  • ClockWednesday 16 October 2019, 17:30-19:30
  • HouseThe Gurdon Institute.

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Megan Oliva Department of Genetics

Title: Effect of Hereditary Spastic Paraplegia genes on presynaptic calcium handling

Abstract: Genes that code for ER-shaping proteins are among the most commonly mutated in the neurodegenerative disease Hereditary Spastic Paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption of the ER network. To investigate how the role of the ER in calcium signalling is affected by this disruption requires tools to interrogate this. We have developed GAL4 -driven genetically encoded Ca2+ indicators targeted to the ER lumen, to record Ca2+ fluxes in identified Drosophila neurons. I will describe the wildtype ER lumenal response to electrical stimulation, and how this is affected in Drosophila mutant for reticulon and REEP genes.

Alex Bates MRC Laboratory of Molecular Biology & University of Cambridge

Title: Using whole-brain connectomics to reveal circuit principles relevant to olfaction and instinctual behaviours

Abstract: Innate olfactory behaviors may depend on developmentally specified circuitry whose detailed patterns of connectivity have evolved over millennia. In contrast some circuits show rapid plasticity based on experience during an animal’s lifetime. We have been investigating odor coding and circuit logic of both learned and innate olfactory pathways in Drosophila, combining connectomics, circuit analysis and behavior. We will present recent progress in this area. In particular we will show how learned and innate circuits are extensively interconnected, a feature which turns out to be critical for memory recall.

This talk is part of the Cambridge Fly Club series.

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