Structural Biology seminar list

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99208619370?pwd=MkR4anNjVFhtbHlIQmRSZzBobWxNdz09.

LMB Seminar: Super-resolution imaging of transcription in living cells

User Ibrahim Cissé, Department of Biological Physics, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

Thursday 11 April 2024, 11:00-12:00

House In person in the LMB's Klug Seminar Room (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/96568201418?pwd=c3F0aCtOeTVwR3IyQzZYdkxoWHdPUT09.

LMB Seminar: Biosynthesis and degradation of the underappreciated green polymer cyanophycin

User Martin Schmeing, Ph.D., James McGill Professor, Department of Biochemistry and Directeur, Centre de recherche en biologie structurale, McGill University.

Thursday 04 April 2024, 11:00-12:00

CANCELLED: LMB Seminar: New therapeutic modalities based on pseudo-natural peptides, products, and neobiologics

User Prof. Hiroaki Suga, Ph.D, The University of Tokyo, Graduate School of Science, Department of Chemistry.

House N/A.

Monday 26 February 2024, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/96572384351?pwd=MkJzbE1qM2dGd0ZSTi9hTmV0elZ5dz09 .

LMB Seminar: Cell volume and dry mass across time scales in cultured mammalian cells: from milliseconds in migrating and circulating cells to homeostasis during cycles of growth and division

User Matthieu Piel, Institut Curie.

Monday 05 February 2024, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/96896374524?pwd=VFJYbkZmRlZQREJ6a1QwelRSdEZwdz09.

LMB Seminar: The allosteric landscape of a protein

User Ben Lehner FRS FMedSci, Head of Generative and Synthetic Genomics, Wellcome Sanger Institute, Cambridge, UK, ICREA Professor, Systems and Synthetic Biology, CRG, Barcelona, ES.

Monday 29 January 2024, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/97161414783?pwd=UEhEZUdDSVVLbDU0Q2lPdFhPQ3M2UT09.

LMB Seminar: From regeneration to homeostasis: tissue-scale decision making

User Pros. Prisca Liberali.

Monday 15 January 2024, 11:00-12:00

CANCELLED LMB Seminar: Alpha-Synuclein and its aggregation in neurodegenerative diseases

User Prof Maria Grazia Spillantini, Professor of Molecular Neurology, University of Cambridge.

House N/A.

Monday 11 December 2023, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/95625236862?pwd=NGttT1d6ay9SWFRqUHMvRWNPdDhyZz09.

LMB Seminar: Power to the protein: analyse, signal and protect with bacterial superglues

User Professor Mark Howarth, University of Cambridge.

Monday 04 December 2023, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/96751041497?pwd=SDgyU1NMdjFVdENscUZqams4Z1RWUT09 .

Crick Lecture 2023: Innovating metagenomics to explore the strange world of archaeal extrachromosomal elements

User Jill Banfield, University of California, Berkeley.

Monday 27 November 2023, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) .

Perutz Lecture 2023: Decoding the protein dance

User Prof. Dr. Paola Picotti, Associate Professor for Molecular Systems Biology, Institute of Molecular Systems Biology, ETH Zurich.

Monday 20 November 2023, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94698100541?pwd=L0RIZUcvY0dvYjhaRW5VU0pXNThKUT09.

LMB Seminar: Pharmacological Adaptation of Proteostasis to Ameliorate Aging-associated Degenerative Diseases

User Jeffery W. Kelly, The Scripps Research Institute.

Tuesday 07 November 2023, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/98196424925?pwd=a0V2Z1FOYU5UZFgreHp1ckQ4Z2UyUT09.

Kendrew Lecture 2023: Cryo-electron tomography or the power of seeing the whole picture

User Wolfgang Baumeister, Max Planck Institute of Biochemistry, Germany.

Monday 30 October 2023, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94069360553?pwd=djJlT09ZOTlENzNJVzRYVnp6WWVZQT09.

LMB Seminar: Talking to cells: biomolecular ultrasound for imaging and control of cellular function in intact organisms

User Mikhail G. Shapiro, Max Delbrück Professor, Caltech.

Tuesday 12 September 2023, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94311710455?pwd=N05mNDk4ZXlDZWdUTzVnaHJTQzRWQT09.

LMB Seminar: Decoding the role of solute carriers in health and disease

User Professor Simon Newstead.

Monday 10 July 2023, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/93130142776?pwd=dEhGKzFGTkw2RGI1enhVSGg0Vm1VZz09.

LMB Seminar: Single-molecule studies reveal the dynamics of replication origin licensing

User Stephen P. Bell, MIT, Dept. of Biology and HHMI.

Monday 03 July 2023, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/92910980652?pwd=U2V6MGFOOU9kbmRnckNaU05HaXl4QT09.

LMB Seminar: What do we know about (your) antibodies? Novel insights from novel techniques in mass spectrometry

User Albert Heck, University of Utrecht, The Netherlands.

Monday 19 June 2023, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/93844733292?pwd=RGczZ0szUnVxVUJOb0U5c1AvbWdhdz09.

LMB Seminar: Blending Proteins: Democratising Access to Beautiful Molecular Landscapes

User Brady Johnston.

Monday 12 June 2023, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/93095291087?pwd=NGRzTnRJb3M0YWxqOC8xQXVNUXBmQT09.

LMB Seminar: Tissue genomics: High throughout tools for measuring and perturbing tissues

User Fei Chen.

Monday 15 May 2023, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/91598384955?pwd=RnE5M0p4bjU3bS8vMjFldHFadE9OZz09.

LMB Seminar: The Extraordinary Life and Legacy of Sir John C. Kendrew

User Professor Paul Wassarman, Mount Sinai, New York.

Tuesday 09 May 2023, 16:00-17:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) .

Milstein Lecture 2023: Understanding the Hox timer by Using mammalian Pseudo-Embryos

User Denis Duboule, Collège de France, Paris France, Federal Institute of Technology (EPFL), Lausanne, Switzerland.

Thursday 26 January 2023, 10:30-11:30

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99349389275?pwd=ZHI3em1DQTA0VTlVLzkvUTN6ZGkxdz09.

LMB Seminar: Engineering a bacteria for lung therapy

User Prof. Luis Serrano.

Tuesday 17 January 2023, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94050407947?pwd=ZFZZYkxhd0JsbGJuMFNHQnlzOSsydz09.

LMB Seminar: Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy

User Tim Clausen, Research Institute of Molecular Pathology (IMP).

Thursday 08 December 2022, 10:00-11:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94108711681?pwd=cXN4VGlQVHBZYkpMUVJ0SXV3emtaUT09.

LMB Seminar: Mechanism and regulation P element transposition in Drosophila

User Donald Rio, Professor of Biochemistry, Biophysics and Structural Biology, Dept. of Molecular and Cell Biology, University of California, Berkeley, USA.

Tuesday 29 November 2022, 16:00-17:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99725572898?pwd=NG82MzVpQmczczAvdkZzN2lJNkt1UT09.

New Frontiers in PKA Signaling

User Susan Taylor, Professor of Chemistry and Biochemistry and a Professor of Pharmacology at the University of California, San Diego.

Wednesday 09 November 2022, 11:30-12:30

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/91021060396?pwd=c1o1TWVTSTNHTWM1dW5lcm54cURKQT09.

Crick Lecture 2022: Neurobiology of Social and Sickness Behaviors

User Catherine Dulac, Higgins Professor of Molecular and Cellular Biology, Lee and Ezpeleta Professor of Arts and Sciences, Howard Hughes Medical Institute Investigator, Department of Molecular and Cellular Biology, Harvard University.

Thursday 03 November 2022, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/96648790745?pwd=Tkx6OVpoY01ieTRMTFMzZ0QvWWR2UT09.

LMB Seminar: Cryo-ET reveals sarcomere structures at molecular resolution

User Prof. Dr. Stefan Raunser, Director, Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund.

Tuesday 18 October 2022, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99553714360?pwd=bVRGN3o1a0dsazJIMnVIemlRbjltZz09.

Regulation of mRNA translation and decay

User David Bartel, Professor of Biology, MIT, HHMI, and Whitehead Institute.

Tuesday 27 September 2022, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/91594582633?pwd=UlBaTk1uTHJ4bW9JbFMwSEZxRE0zdz09.

LMB Seminar: Encoding tissue morphogenesis with genetics, mechanics and geometry

User Professor Thomas Lecuit, Group leader at IBDM and Turing Center for living systems, Marseille. Professor at Collège de France, Paris.

Thursday 08 September 2022, 11:00-12:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94050407947?pwd=ZFZZYkxhd0JsbGJuMFNHQnlzOSsydz09.

Milstein Lecture 2022 - Project Lightspeed – The discovery of the first Covid-19 mRNA Vaccine

User Özlem Türeci, M.D., Professor Personalized Cancer Immunotherapy, Johannes Gutenberg University Mainz, Co-founder, CMO BioNTech, Germany.

Tuesday 26 July 2022, 11:30-12:30

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/94050407947?pwd=ZFZZYkxhd0JsbGJuMFNHQnlzOSsydz09.

Milstein Lecture 2022 - mRNA Cancer Vaccines

User Ugur Sahin, M.D., Professor Translational Oncology & Immunology, Johannes Gutenberg University Mainz, Co-founder, CEO BioNTech, Germany.

Tuesday 26 July 2022, 10:00-11:00

House In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoom, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/91661708050?pwd=WS9Ua0czQm9FaC9qaWk3S2VQMjE5dz09.

LMB Seminar - Using connectomes to accelerate studies of the neuronal control of behavior in Drosophila

User Gerald M. Rubin, Senior Group Leader, Janelia Research Campus, HHMI, LMB Fellow.

Thursday 26 May 2022, 11:00-12:00

House Registration via https://www3.mrc-lmb.cam.ac.uk/sites/klug/.

Aaron Klug Memorial Symposium

User Various - see Further Information.

Friday 20 May 2022, 09:00-17:00

House Zoom link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99780084619?pwd=V3RmYTdTbmlBLzFLd1NOR0hHcjFIZz09.

Kendrew Lecture 2022: Chemogenetic and optogenetic technologies for probing molecular and cellular networks

User Alice Ting - Professor of Genetics, of Biology and, by courtesy, of Chemistry, Stanford University, USA and Chan Zuckerberg Biohub Investigator .

Thursday 12 May 2022, 16:00-17:00

House Zoom link: https://mrc-lmb-cam-ac-uk.zoom.us/j/97051627883?pwd=cUh3ZDZkT3I2bHdxVXo0TytZSEJkdz09.

LMB Seminar: Engineering Organoid Development

User Professor Matthias Lutolf, Roche Institute for Translational Bioengineering, Basel, Switzerland and Laboratory of Stem Cell Bioengineering, EPFL, Switzerland.

Tuesday 19 April 2022, 11:00-12:00

House Zoom: https://mrc-lmb-cam-ac-uk.zoom.us/j/92288963882?pwd=MEFqUURaRmJ1dkpTNkl1dzhDcHE2QT09.

Max Perutz Lecture 2022: Therapeutic Opportunities in Glycoscience

User Carolyn Bertozzi, Anne T. and Robert M. Bass Professor of Chemistry, Baker Family Director, Stanford ChEM-H, Howard Hughes Medical Institute Investigator, Stanford University.

Tuesday 29 March 2022, 16:00-17:00

House Zoom: https://mrc-lmb-cam-ac-uk.zoom.us/j/96610458150?pwd=RmI5RUZZU0JRNzBBNlh3NnFWQWpjZz09.

Milstein Lecture 2021: Organoids to model human diseases

User Hans Clevers, Professor in Molecular Genetics, Hubrecht Institute, Utrecht, The Netherlands.

Tuesday 30 November 2021, 11:00-12:00

House Zoom: https://mrc-lmb-cam-ac-uk.zoom.us/j/98167346283?pwd=UStva0JBNFpiNTE4czlSS283WGJlQT09.

Crick Lecture 2021: Human Immune Responses to SARS-CoV-2 Infection or Vaccination

User Michel C. Nussenzweig, Zanvil A. Cohn and Ralph M. Steinman Professor, The Rockefeller University, New York, USA.

Monday 15 November 2021, 11:00-12:00

House Zoom: https://mrc-lmb-cam-ac-uk.zoom.us/j/92866604568?pwd=TlljTHk5VGEzd2YzM3JHQkxOaWdRUT09.

Interplay between tissue tension and tumor immunity

User Valerie Weaver, Director of the Center for Bioengineering and Tissue Regeneration and Professor in the Department of Surgery, UCSF, USA.

Tuesday 02 November 2021, 16:00-17:00

House Webinar - https://zoom.us/j/92425532683?pwd=bXhPUkh0dm8xRlVmUkthREQwUnc4UT09.

LMB Seminar: Biomolecular condensates and their implications for physiology and disease

User Tony Hyman, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Tuesday 19 October 2021, 11:00-12:00

House YouTube link to watch the talk: https://youtu.be/6hlgADbBvZs.

LMB Kendrew Lecture (part 2): Highly accurate protein structure prediction with AlphaFold

User John Jumper, Research scientist and AlphaFold lead.

Wednesday 13 October 2021, 16:00-17:00

House YouTube link to watch the talk: https://youtu.be/6hlgADbBvZs.

LMB Kendrew Lecture (part 1): Using AI to accelerate scientific discovery

User Demis Hassabis, Founder & CEO DeepMind, AlphaFold project lead.

Wednesday 13 October 2021, 14:30-15:30

House Webinar - https://zoom.us/j/99447632193?pwd=QU9vbXliNXcvcXZqVFFBbHVpd2tSUT09.

Using stem cell technology to combat age-related neurodegenerative diseases

User Sally Temple PhD, Scientific Director, Neural Stem Cell Institute, USA.

Tuesday 27 July 2021, 16:00-17:00

House Webinar - https://zoom.us/j/93763520674?pwd=WTlDZThITTFUaEpKL2xMZ1YzZWVkZz09.

LMB Seminar: The biomass distribution on Earth

User Ron Milo, Professor, Department of Plant and Environmental Sciences, Weizmann Institute of Science, Israel.

Tuesday 06 July 2021, 11:00-12:00

House Webinar - https://zoom.us/j/97224999053?pwd=aitsUFFSQ3dKVlM0MUFVWC83S0E0UT09.

LMB Seminar: Membrane Mechanics: cryo-EM insights and challenges

User Adam Frost, Associate Professor, Biochemistry and Biophysics, UCSF, USA.

Tuesday 29 June 2021, 16:00-17:00

House Webinar - https://zoom.us/j/91953336333?pwd=ZnV2R1dNSW1FdVhmK1J6UmcvdnNOdz09.

LMB Seminar: Mechanisms of centriole assembly

User Pierre Gönczy, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland.

Tuesday 22 June 2021, 11:00-12:00

House Webinar - https://zoom.us/j/91953336333?pwd=ZnV2R1dNSW1FdVhmK1J6UmcvdnNOdz09.

Mechanisms of centriole assembly

User Pierre Gönczy, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland.

Tuesday 22 June 2021, 11:00-12:00

House Webinar - Zoom link: https://zoom.us/j/91691820397?pwd=aUNFUFFib1V5S2V4RUswRmlhN0pRQT09.

LMB Seminar: Systemic regulation of brain aging and function

User Tony Wyss-Coray, D. H. Chen Professor II, Stanford University, USA.

Tuesday 25 May 2021, 16:00-17:00

House Webinar - https://zoom.us/j/92141784758?pwd=MC9UVVBLaUdkTkg4dDdJb2RRaGhmUT09.

Perutz Lecture 2021: The coming of age of de novo protein design

User Professor David Baker, Director of the Institute for Protein Design, University of Washington, USA .

Tuesday 27 April 2021, 16:00-17:00

House Webinar - https://zoom.us/j/97074945822?pwd=NWZvc3VEVWJxWmREVXJhaisxTkJ5dz09.

LMB Seminar: Molecular views into cellular functions by in-cell cryo-electron tomography

User Dr Julia Mahamid, Group Leader, EMBL Heidelberg, Germany.

Tuesday 20 April 2021, 11:00-12:00

House Webinar - https://zoom.us/j/97041423092?pwd=dDFuelNtb0o2cTdWL1BabFBhbldFQT09 .

LMB Seminar: Functions of Ribosome-Associated Chaperones in Health and Disease

User Prof. Dr. Elke Deuerling, Chair of Molecular Microbiology, University of Konstanz, Germany.

Tuesday 16 March 2021, 11:00-12:00

House Webinar - https://zoom.us/j/92208122335?pwd=UGJIN3k3TnJYNWloNFBhVDlOaldZUT09.

Rules of engagement: molecular arms races between host and viral genomes

User Dr. Harmit Singh Malik, Professor, Division of Basic Sciences & HHMI Investigator, Fred Hutchinson Cancer Research Center.

Tuesday 02 March 2021, 16:00-17:00

House Webinar - https://zoom.us/j/95280655660?pwd=RzhzSlQvWXFVS1dVdURPUUxocElkQT09 Passcode: 628922.

Translation defects and neurological disease

User Susan L Ackerman, PhD. Professor, Cellular and Molecular Biology Steven W. Kuffler Chair of Biology University of California San Diego USA/HHMI.

Tuesday 08 December 2020, 16:00-17:00

House Webinar - register at https://nanoscience.oxinst.com/campaigns/sir-martin-wood-prize-lecture.

Sir Martin Wood Prize Lecture: The emerging world of microbial rhodopsins in photobiology

User Keiichi Inoue, Associate Professor, The Institute for Solid State Physics, The University of Tokyo.

Thursday 26 November 2020, 11:00-12:00

House Webinar (via Zoom online).

The African killifish: a vertebrate model to understand aging and ‘suspended animation'

User Anne Brunet, Michele and Timothy Barakett Professor of Genetics, Stanford University, USA.

Tuesday 03 November 2020, 16:00-17:00

How is electrical signal generated?

User Nieng Yan, Shirley M. Tilghman Professor of Molecular Biology, Princeton University, USA.

House Webinar via Zoom.

Monday 02 November 2020, 16:00-17:00

RNP granules in health and disease (via Zoom)

User Roy Parker, Investigator, Howard Hughes Medical Institute, Executive Director, BioFrontiers Institute, Distinguished Professor and Cech-Leinwand Endowed Chair of Biochemistry, University of Colorado Boulder, USA.

House Webinar via Zoom.

Tuesday 22 September 2020, 16:00-17:00

House Webinar via Zoom - https://zoom.us/j/97493748184?pwd=Z1dZM2pxUk16QytPeU5NVWZ3bnZmdz09 Meeting ID: 974 9374 8184 Passcode: 404662.

Study virus assembly and host interactions in vitro and in cells by cryoEM and cryoET

User Peijun Zhang, Professor of Structural Biology and Wellcome Trust Investigator, University of Oxford .

Tuesday 08 September 2020, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Perutz LMB Seminar Series: How our chromosomes are replicated

User John Diffley, Associate Research Director, the Francis Crick Institute, London, UK.

Wednesday 26 February 2020, 11:00-12:00

House Max Perutz Lecture Theatre, MRC Laboratory of Molecular Biology.

LMB Seminar: Mitochondrial Behaviour

User Jodi Nunnari, Distinguished Professor, Department of Molecular and Cellular Biology, Univeristy of California, Davis.

Tuesday 25 February 2020, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Milstein LMB Seminar Series: Stem Cells in Silence, Action and Cancer

User Elaine Fuchs, Rebecca C. Lancefield Professor Investigator, Howard Hughes Medical Institute .

Monday 27 January 2020, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series: Host factors that shape influenza evolution.

User Wendy Barclay.

Friday 06 December 2019, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series: Folding and assembly of newly synthesized proteins revealed by ribosome profiling

User Bernd Bukau, Center for Molecular Biology of Heidelberg University and German Cancer Research Center.

Thursday 21 November 2019, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - Kendrew Lecture - How a ubiquitin-like protein brings ubiquitylation to life

User Brenda Schulman, Director at the Max Planck Institute of Biochemistry.

Thursday 03 October 2019, 10:30-11:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - Organelle contact sites: a new layer in the organization of Eukaryotic cells

User Benoit Kornmann, Associate professor – Dept. of Biochemistry, Oxford University, and C.W. Maplethorpe Tutorial Fellow in Bio-chemistry – St-Hugh’s College, Oxford University.

Thursday 12 September 2019, 10:30-11:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - Antibodies against Ebola and Lassa: A Global Collaboration

User Erica Ollmann Saphire, Professor Department of Immunology and Microbiology California Campus.

Tuesday 23 July 2019, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - Francis Crick Lecture - Innovation by Evolution: Bringing New Chemistry to Life

User Frances Arnold, California Institute of Technology, Pasadena, U.S.A..

Thursday 18 July 2019, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

What next for your career in science?

User Rebecca Aarons, Jenny Gallop, Emma Gleave.

Friday 28 June 2019, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - Structural and mechanistic studies of key components in DNA damage signalling and repair

User Xiaodong Zhang.

Tuesday 18 June 2019, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series: Folding and assembly of newly synthesized proteins revealed by ribosome profiling

User Bernd Bukau, Center for Molecular Biology of Heidelberg University and German Cancer Research Center.

Friday 14 June 2019, 10:30-11:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - Towards a mechanistic understanding of cellular processes by cryo-EM

User Gaia Pigino, Research Group Leader at the MPI-CBG.

Tuesday 28 May 2019, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - The 100,000 genomes project and beyond

User Tim Hubbard, Professor of Bioinformatics & Head of Department, King’s College London.

Thursday 23 May 2019, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series: Title tbc

User Nieng Yan, Professor of Molecular Biology, Princeton University.

Saturday 18 May 2019, 00:00-00:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - Modifications of RNA: their function and role in cancer

User Tony Kouzarides, PhD FRS FMedSci, Professor of Cancer Biology, Cancer Research UK Gibb Fellow, Director of the Milner Therapeutics Institute, Member of the Department of Pathology.

Thursday 16 May 2019, 10:30-11:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - Synthesis and hydrolysis of the gram-positive cell wall: revisiting old models with new data

User David Rudner, Dept. of Microbiology and Immunobiology, Harvard Medical School.

Friday 03 May 2019, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - CryoEM of proton pumping macromolecular machines

User John Rubinstein.

Monday 29 April 2019, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - Factors and Functions of ER Membrane Contact Sites

User Gia Voeltz PhD, HHMI Investigator and Professor University of Colorado at Boulder.

Wednesday 10 April 2019, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - Pathogen restriction and host specificity: insights from the human pathogen Salmonella Typhi

User Jorge Galan, PhD, DVM, Lucille P. Markey Professor of Microbial Pathogenesis and Professor of Cell Biology; Chair, Department of Microbial Pathogenesis.

Friday 05 April 2019, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series: Title tbc

User Gerry Rubin, Vice President, HHMI, and Executive Director, Janelia Research Campus.

Wednesday 03 April 2019, 00:00-00:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series: Title tbc

User Gerry Rubin, Vice President, HHMI, and Executive Director, Janelia Research Campus.

Wednesday 03 April 2019, 00:00-00:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series: Title tbc

User Julie Ahringer, PhD FMedSci, Director, Wellcome Senior Research Fellow, Professor of Genetics and Genomics, Member of the Department of Genetics.

Wednesday 27 March 2019, 00:00-00:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series: Title tbc

User Julie Ahringer, PhD FMedSci, Director, Wellcome Senior Research Fellow, Professor of Genetics and Genomics, Member of the Department of Genetics.

Wednesday 27 March 2019, 00:00-00:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - ANNA KARENINA AND THE GENETICS OF COMPLEX DISEASE: DE NOVO MUTATIONS IN SCHIZOPHRENIA

User Mary-Claire King, human geneticist professor, University of Washington.

Thursday 14 March 2019, 10:30-11:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - Animating Molecular Biology

User Janet Iwasa, Assistant Professor, Biochemistry Department, University of Utah.

Friday 08 March 2019, 11:30-12:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series Milstein Lecture - Intracellular Membrane Contact Sites, Lipid Dynamics and Neurodegeneration

User Pietro De Camilli Departments of Neuroscience and Cell Biology, Howard Hughes Medical Institute, Kavli Institute for Neuroscince, Yale University School of Medicine.

Tuesday 05 March 2019, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - Stem cells, regeneration and organoid cultures

User Meritxell Huch, Wellcome Sir Henry Dale Fellow, Member of the Department of Physiology, Development and Neuroscience.

Thursday 28 February 2019, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

tRNA Modifications and Decoding Errors

User Professor Eric Westhof (Institut de Biologie Moléculaire et Cellulaire du CNRS, Université de Strasbourg).

House Jean Thomas Lecture Theatre, Sanger Biochemistry Building.

Wednesday 20 February 2019, 16:00-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series-Epigenetic inheritance in mammals

User Anne Ferguson Smith, Department of Genetics, Wellcome Trust Senior Investigator.

Wednesday 30 January 2019, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

A Saposin-lipoprotein nanoparticle system for membrane proteins

User Dr Jens Frauenfeld (CEO Salipro Biotech, Sweden).

House Jean Thomas Lecture Theatre, Sanger Biochemistry Building.

Monday 03 December 2018, 15:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series-Solving a 3D jigsaw with 1000 pieces - Structure and assembly of the nuclear pore complex

User Martin Beck.

Monday 03 December 2018, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Perutz Lecture- How synapses work: Architecture and mechanism of neurotransmitter receptors and transporters

User Eric Gouaux.

Thursday 29 November 2018, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Capturing the 3D Folds of Whole Mammalian Genomes in Single Cells

User Dr Tim Stevens (Cell Biology Division, LMB).

House Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 28 November 2018, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series-Title to follow

User Carrie Partch.

Tuesday 20 November 2018, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Reconstructing Tissue Architecture by Single Cell Genomics

User Sarah Teichmann.

Thursday 15 November 2018, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series-Mycobacterium tuberculosis infection of host cells in time and space

User Max Gutierrez.

Thursday 01 November 2018, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Protein:protein recognition in the Ubiquitin Proteasome-degradation System (UPS) and Membrane Surface Complexes from the Ras-family

User Dr Andrew Byrd (Head of Macromolecular NMR, National Cancer Institute, Maryland).

House Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 31 October 2018, 16:00-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Light Sleep

User Gero Miesenboeck.

Wednesday 24 October 2018, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Evidence that sub-cellular oscillators may time and execute organelle biogenesis

User Jordan Raff.

Thursday 20 September 2018, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series - Kinetochore Structure

User Steve Harrison.

Thursday 28 June 2018, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural studies of a DNA unwinding machine

User Dr Laura Spagnolo (University of Glasgow).

House Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 20 June 2018, 10:15-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Architecture of PIKK Kinases and their molecular mechanisms of regulation

User Dr Taiana De Oliveira (Astra Zeneca).

House Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 20 June 2018, 10:15-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Protein and Peptide Mass Spectrometry Analysis

User Dr Anja Andrejeva (Cambridge Centre for Proteomics).

House Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 06 June 2018, 10:30-11:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series-Title to follow

User Michael Hall.

Tuesday 29 May 2018, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series-Title to follow

User Titia De Lange Rockefeller.

Wednesday 23 May 2018, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Solution-based angular measurements of protein structure and conformational change by second-harmonic generation (SHG)

User Dr Joshua Salafsky (Founder and CSO, Biodesy Inc, San Francisco).

House Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 23 May 2018, 10:30-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Fragment based inhibition of CK2α

User Dr Paul Brear (Hyvonen Group).

House Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 16 May 2018, 10:30-11:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Correlative tweezers fluorescence microscopy: one step towards real-time single-molecule biology

User Dr Joanna Andrecka (Lumicks).

House Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 09 May 2018, 10:30-11:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Kendrew Lecture-Electron cryo-microscopy

User Jacques Dubochet.

Thursday 26 April 2018, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Substrate reduction enabled by structural biology as therapy for metabolic disorders

User Dr Gustavo Arruda Bezerra (Structural Genomics Consortium – University of Oxford).

House Perham Seminar Room, Sanger Biochemistry Building.

Wednesday 25 April 2018, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Toward the Reconstitution of the Maturation of Okazaki Fragments Multiprotein Complex in Human at the Single Molecule Level

User Dr Luay Joudeh (Pellegrini Group).

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 28 March 2018, 10:15-11:15

Using Computational Structure Biology to Study Diseases that cause Major Health Concerns in Brazil

User Dr Pedro Torres.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 21 March 2018, 10:30-11:30

Not Too Big - Not Too Small: Fragment Antibody Drug Candidates as Alternatives to Antibodies for Solid Tumours

User Dr Gokhan Yahioglu (Director of Medicinal Chemistry, Antikor Biopharma Ltd).

Monday 19 March 2018, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series-Title to follow

User Lukas Kapitein.

Thursday 15 March 2018, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Mycobacterium Tuberculosis Physiology: The Intricate Interplay between Drug Tolerance and Drug Resistance

User Caroline Pule (Faculty of Medicine, Stellenbosch University, South Africa).

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 07 March 2018, 10:15-11:15

Shortening Tuberculosis Chemotherapies: Elucidating the Molecular genetic programs of persistence of M. tuberculosis

User Professor W. Jacobs, Howard Hughes Medical Institute, NY.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Monday 26 February 2018, 10:15-11:15

Human 2-oxoacid-dependent Oxygenases

User Dr M. S. Islam (Department of Biochemistry, University of Cambridge).

Wednesday 24 January 2018, 10:30-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Kendrew Lecture- Illuminating biology at the nanoscale and systems scale by imaging

User Xiaowei Zhuang .

Monday 15 January 2018, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The simple reason that M. avium subspecies paratuberculosis has been missed as a major human pathogen is that, unknowingly, it's been treated since 1942

User Dr Robert Greenstein (VA Medical Center, Bronx, NY).

Wednesday 13 December 2017, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Localised RNA-based mechanisms underlie neuronal wiring

User Christine Holt.

Monday 04 December 2017, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Exploring and Exploiting the Diversity of Secretory Routes in Mammalian Cells

User Franck Perez.

Tuesday 28 November 2017, 14:00-15:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Genomic and cellular integration of bacterial endosymbionts into host cells

User John McCutcheon.

Friday 03 November 2017, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Signalling through interleukin/interferon receptors: outside and inside of the cell

User Dr. Alexander Wlodawer (Chief, Macromolecular Crystallography Laboratory, NCI-Frederick).

Wednesday 11 October 2017, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series- Stories from the first year of the Central Oxford Structural Microscopy and Imaging Centre - closing in on bacterial protein secretion systems.

User Susan Lea.

Monday 02 October 2017, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series- How T cells control secretion to optimise target cell killing

User Gillian Griffiths.

Tuesday 19 September 2017, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Crick Lecture-The Surprising Chemistry of Non-enzymatic RNA Replication

User Jack Szostack, Harvard, USA .

Thursday 07 September 2017, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Integrated structural biology of gene transcription

User Patrick Cramer, Max Planck Institute.

Tuesday 05 September 2017, 16:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series-RNA quality control and the nuclear RNA exosome

User Chris Lima.

Friday 14 July 2017, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series- Title to follow

User Andreas Matouschek, Northwestern University, USA.

Monday 03 July 2017, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

LMB Seminar Series-DNA Methylation: From stem cell differentiation to chromatin organisation

User Margaret Goodell.

Tuesday 20 June 2017, 11:15-12:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Linking Structural Biology and Clinical Genomics: Purine Nucleotidase in Relapsed Leukemia

User Dr. Aleš Hnízda (Academy of Sciences of the Czech Republic, Prague; From 1st June: Department of Biochemistry, University of Cambridge).

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 31 May 2017, 10:15-11:15

Revolutionary Cryo-EM: the Potential Power to Visualize High Resolution Dynamic Structures

User Dr Kai Zhang (LMB).

Wednesday 24 May 2017, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Charting the response to DNA damage

User Dan Durocher, University of Toronto, Faculty of Medicine.

Monday 15 May 2017, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Rebuilding the HDX-MS Method to Support Integrative Methods in Structural Biology

User Dr David Schriemer (University of Calgary, Alberta).

Wednesday 10 May 2017, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Mulitispectral imaging to uncover the organelle interactome

User Jennifer Lippincott-Schwartz, National Institute of Health, Maryland, USA.

Monday 08 May 2017, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Max Perutz Lecture- Antisense transcription and epigenetic switching

User Caroline Dean, John Innes Centre, Norwich.

Thursday 27 April 2017, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

High-Throughput Fragment-Based Drug Discovery at Diamond Synchrotron: Robots can do much of the work to screen in FBDD!

User Prof Frank von Delft (Diamond Light Source / Structural Genomics Consortium - Oxford).

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Monday 03 April 2017, 10:15-11:15

COSMIC Catalogue of Cancer Mutations and the 3D Proteome

User Simon Forbes & Harry Jubb (Sanger Institute, Wellcome Genome Campus).

Wednesday 29 March 2017, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

RNA methylation in development and disease

User Michaela Frye, Stem Cell Institute and Department of Genetics, Cambridge.

Friday 24 March 2017, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dynamic interactions and fuzzy structures in protein complexes and higher-order assemblies

User Dr Monika Fuxreiter.

House Biochemistry Lecture Theatre, Sanger Building.

Thursday 23 March 2017, 10:15-11:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Using Integrative Methods in Structural Biology to Understand Protein Structure

User Dr Daniel Saltzberg (University of California, San Francisco).

Wednesday 08 March 2017, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Membrane proteins - the lipid connection

User Carol Robinson, university of Oxford.

Tuesday 07 March 2017, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Computational study of mutations in proteins

User Professor Douglas Pires (Centro de Pesquisas René Rachou, FIOCRUZ - Minas Gerais, Brazil).

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 01 March 2017, 10:15-11:15

Myc and MexR: conformational selection and fuzzy complexes in transcriptional regulation

User Prof Maria Sunnerhagen (Linkoping University, Sweden).

House Biochemistry Lecture Theatre, Sanger Building.

Tuesday 28 February 2017, 14:30-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Milstein Lecture- Molecular Mechanisms of Synaptic Transmission

User Thomas Südhof, Department of Molecular and Cellular Physiology, Stanford.

Thursday 09 February 2017, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

What's new at PDBe?

User Dr Deepti Gupta and Dr John Berrisford (PDBe).

Wednesday 25 January 2017, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Comparative studies of intrinsically disordered proteins

User Professor Jane Clarke, Department of Chemistry, University of Cambridge .

Monday 23 January 2017, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Phosphoproteomic strategies reveal global impact of kinase inhibitors on regulatory kinase networks and the phosphoproteome

User Prof David Litchfield (University of Western Ontario).

Wednesday 16 November 2016, 14:30-16:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Molecular Chaperone Functions in Protein Folding and Quality Control

User Ulrich Hartl, max Planck Institute of Biochemistry.

Tuesday 15 November 2016, 12:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

A computational framework for optimizing combination drug therapies

User Dr Michael Lyons (Colorado State University).

Wednesday 26 October 2016, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Kendrew Lecture- Bacterial Quorum Sensing and its Control

User Bonnie Bassler, Princeton University, USA .

Monday 24 October 2016, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structure and Function of TIFA - A New Player in Immunity and Cancer

User Prof Ming-Daw Tsai (Academia Sinica in Taiwan).

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Monday 10 October 2016, 15:00-16:00

Interactive molecular dynamics for improved model building and exploration in structural biology

User Dr Tristan Croll (CIMR, Cambridge).

Wednesday 28 September 2016, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

TBC

User Amita Sehgal.

Tuesday 27 September 2016, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Predicting the impact of natural and disease variants on protein function

User Professor Rob Russell (Heidelberg University).

Wednesday 13 July 2016, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

TBC

User Laurence Pearl, Sussex.

Tuesday 12 July 2016, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

TBC

User Richard Youle.

Friday 01 July 2016, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Targeting Trehalose and Methylglucose Lipopolysaccharide Pathways of M. tuberculosis

User Nupur Verma (Department of Biochemistry, Cambridge).

Wednesday 15 June 2016, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Pathological vs Reversible Amyloid

User David Eisenberg, University of California.

Friday 10 June 2016, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Pathological vs Reversible Amyloid

User Prof. David Eisenberg, Dept. Chemistry and Biochemistry, University of California.

Friday 10 June 2016, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Perutz Lecture 2016

User Ron Vale, University of California.

Thursday 02 June 2016, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

TBC

User Dr Owen Davies (Newcastle University).

Wednesday 01 June 2016, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Kendrew lecture- Post-translational regulation of cell signalling

User Tony Hunter.

Wednesday 25 May 2016, 15:00-16:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Matching density maps of macromolecular assemblies from Cryo-EM and assessment of fitted atomic models

User Dr Agnel Praveen Joseph.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 25 May 2016, 10:15-11:15

The 3D structures of genomes in single cells reveal principles of nuclear organization

User Dr Tim Stevens (LMB, Cambridge).

Wednesday 18 May 2016, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Mapping cancer origins

User Proffessor Richard Gilbertson, Cancer Research UK, Cambridge.

Tuesday 03 May 2016, 12:00-13:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The E. coli replisome caught in the act by cryo-EM and single molecule microscopy

User Dr Meindert Lamers (LMB).

Wednesday 27 April 2016, 14:00-15:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Learning and motivation toggle feed-forward inhibition in the Drosophila mushroom body

User Scott Waddell.

Wednesday 27 April 2016, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

CRISPR-Cas: origin of adaptive immunity from selfish genetic elements and the evolutionary continuum from Darwin to Lamarck

User Eugene Koonin.

Friday 18 March 2016, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structure of TRP channel by single particle cryo-EM

User Yifan Cheng.

Wednesday 16 March 2016, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Cell wall deficient (L-form) bacteria: from cell biology to the origins of life

User Jeff Errington.

Thursday 03 March 2016, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Pregnancy outcome prediction using placenta epigenetic data

User Dr Sung Gong (Clinical School of Medicine).

Wednesday 02 March 2016, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

mRNA stability is substantially dictated by the action of the ribosome

User Rachel Green, Johns Hopkins University, School of Medicine.

Thursday 25 February 2016, 10:30-11:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Crick 2016 Lecture-DNA Sequence and the Epigenome Entwined

User Adrian Bird.

Tuesday 16 February 2016, 11:30-12:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

A chemical approach to understanding cell division

User Ulrike Eggert.

Tuesday 02 February 2016, 16:15-17:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Protein folding homeostasis in the endoplasmic reticulum: tuning a chaperone

User David Ron, University of Cambridge.

Friday 29 January 2016, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Protein transport to the endoplasmic reticulum

User Dr Rebecca Voorhees (LMB).

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 20 January 2016, 10:15-11:15

Computational approaches to investigate protein-nucleic acid and protein-protein interactions

User Dr Sony Malhotra (Department of Biochemistry).

Wednesday 16 December 2015, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Milstein Lecture-Phosphoinositide 3-Kinase and Cancer Metabolism

User Lewis Cantley, Meyer Cancer Center, Weill Cornell Medicine and New York Presbyterian Hospital, New York.

Monday 14 December 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Mapping of ligand binding site and activation mechanism of APJ receptor

User Prashant Kumar (Department of Biochemistry).

Wednesday 02 December 2015, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

In the beginning it was dark: Hydrothermal vents and the origin of life (real microbes)

User William Martin, Universität Düsseldorf.

Thursday 26 November 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Paul Brear - Inhibiting CK2α from outside the active site

User Paul Brear - Department of Biochemistry.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 25 November 2015, 10:15-11:15

Prof Song Tan - TBC

User Professor Song Tan (Penn State University).

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 18 November 2015, 10:15-11:15

Fitting atomic structures into EM density maps

User Dr Arun Prasad Pandurangan (Department of Biochemistry).

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 04 November 2015, 10:15-11:15

Migle Kisonaite - "Structure of Gremlin-1: Insights into the Mechanism of Bone Morphogenetic Protein Antagonism" and Xuelu Wang "Understanding of the Pro-domain in TGF-β Superfamily: Structure and Characterisation of Pro-activin A"

User Xuelu Wang and Migle Kisonaite - Department of Biochemistry.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 28 October 2015, 10:15-11:15

ARCIMBOLDO, an ab initio approach to MR phasing

User Isabel Uson (Molecular Biology Institute of Barcelona).

Wednesday 21 October 2015, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Crick Lecture- The transformative CRISPR-Cas9 genome engineering technology: lessons learned from bacteria

User Emmanuelle Charpentier .

Friday 02 October 2015, 15:15-16:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Plasticity of Cancer Cells : Lessons from Glioblastoma

User Inder Verma, Salk Institute for Biological Studies.

Friday 04 September 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Atomic resolution cryoEM structure of bacteriophage

User Prof. Wah Chiu, Baylor College of Medicine, Texas.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 02 September 2015, 10:15-11:15

Modulating Protein-Protein Interactions

User Dr Jessica Holien - St. Vincent's Institute for Medical Research.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 26 August 2015, 15:00-16:00

Title to be confirmed

User Dr Dijana Matak-Vinkovic, Dept. Chemistry, Cambridge.

Wednesday 24 June 2015, 10:15-11:15

House Centre for Molecular Informatics, Dept. of Chemistry.

Crystallography & Compchem Hack Weekend 20/21 June

User Speaker to be confirmed.

Saturday 20 June 2015, 09:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural Biology and Transmembrane Signalling: Understanding a 'Double-edged' Receptor, DCC

User Jia-Huai Wang (Harvard).

Wednesday 17 June 2015, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Persister Cells and the Search for Sterilizing Antibiotics

User Kim Lewis.

Monday 15 June 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Impact of rapid whole-genome sequencing on diagnostic and public health microbiology

User Dr Claudio U. Köser, Dept. Medicine and Wellcome Trust Genome Campus.

Wednesday 03 June 2015, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structural Mechanisms in the Tyrosine Kinases that Initiate Immunological Signaling

User Professor John Kuriyan, University of California.

Thursday 21 May 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural Mechanisms in Protein Kinase Regulation

User Professor John Kuriyan, Berkeley.

Wednesday 20 May 2015, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Regulation of proteasome function in normal and disease states

User Professor Alfred Goldberg, Harvard Medical School.

Friday 15 May 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Predicting drug-target binding kinetics through enhanced sampling simulations

User Professor Francesco Gervasio, Dept. Chemistry, University College London.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 13 May 2015, 10:15-11:15

Biodiversity and Drug Discovery

User Professor Glaucius Oliva, Universidade de São Paulo.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Thursday 07 May 2015, 16:30-17:30

Recent advances in high resolution cryo-EM structure determination

User Xiaochen Bai, LMB-MRC.

Wednesday 29 April 2015, 10:15-11:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Chromatin unloading of the replicative DNA helicase during replication and repair

User Johannes Walter.

Wednesday 08 April 2015, 16:15-17:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Insights from a model of breast tumor heterogeneity

User Greg Hannon, CRUK, Cambridge.

Thursday 26 March 2015, 16:15-17:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Remodeling of the erythroid proteome

User Dan Finley, Harvard.

Tuesday 17 March 2015, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Synthetic Probes for live-cell imaging

User Kai Johnsson.

Wednesday 11 March 2015, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tbc

User Jeff Errington.

Tuesday 03 March 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Meindert Lamers - Title to be confirmed

User Dr Meindert Lamers - LMB.

House Biochemistry Seminar Room, Sanger Building, Tennis Court Road.

Wednesday 25 February 2015, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Prion propagation and neurotoxicity

User Prof. John Collinge, UCL .

Thursday 19 February 2015, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Isaac Westwood - Title to be Confirmed

User Dr Isaac Westwood - Institute of Cancer Research.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 18 February 2015, 10:15-11:30

Dr Christian Ottmann, Title to be confirmed

User Dr. Christian Ottmann Associate Professor, (UHD) Molecular Cell and Structural Biology, Chemical Biology, Dpt. of Biomedical Engineering and Institute for Complex Molecular Systems, Technische Universiteit, EINDHOVEN.

Wednesday 04 February 2015, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Taming a protein destruction machine

User Nicolas Thoma, Friedrich Miescher Institute for Biomedical Reearch, Basel, Switzerland.

Thursday 29 January 2015, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Investigating the human proteasome by cryo-EM - an emerging tool for structural based drug design

User Dr Paula de Fonseca - MRC LMB.

Wednesday 28 January 2015, 10:15-11:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Title to be confirmed

User David Ron, Cambridge University.

Tuesday 27 January 2015, 16:15-17:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Dr Takashi Ochi and Dr Qian Wu

User Dr Takashi Ochi, Department of Biochemistry, University of Cambridge, u. k.

Wednesday 21 January 2015, 10:15-11:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Local and Global Regulation of Meiotic Prophase by Post-Translational Protein Modification

User Neil Hunter.

Monday 15 December 2014, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Max Perutz Lecture 2014: C. elegans surveillance of conserved cellular components to detect and defend pathogen attacks, real or imagined

User Gary Ruvkun, MGH Harvard.

Friday 05 December 2014, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Tools for refinement against low resolution X-ray data and fit to EM reconstructions

User Dr Garib Murshudov, LMB, MRC.

House Biochemistry Lecture Theatre, Sanger Building, Tennis Court Road.

Wednesday 03 December 2014, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Identification and characterization of interaction sites with MD simulations of mixed solvents – Application to non-standard targets

User Professor Xavier Barril, ICREA Research Professor at Barcelona University, Spain.

Wednesday 12 November 2014, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The amazing hepatocyte: master of disguise and adaptation

User Dr Markus Grompe.

Monday 10 November 2014, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Genome stability and instability during repair of a broken chromosome

User Jim Haber, Director, Rosenstiel Basic Medical Sciences Research Center.

Thursday 06 November 2014, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

(1) An introduction to Gene Synthesis - capabilities and uses. (2) An introduction to precise genome editing with TAL effectors and CRISPR

User Nikolai Netuschil and Nahush Karnataki. ThermoFisher Scientific.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 29 October 2014, 10:15-11:15

Support Science and Diamond Light Source

User Carina Lobley, DLS.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 15 October 2014, 10:15-11:15

Professor Randy Read - title to be comfirmed

User Professor Randy Read, CIMR, Cambridge.

House Seminar Room 2, Hopkins Building.

Wednesday 08 October 2014, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Crick Lecture 2014: How Aneuploidy Drives Cancer

User Stephen Elledge, Gregor Mendel Professor of Genetics, Department of Genetics, Harvard Medical School.

Friday 19 September 2014, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Feedback control of cell division

User Andrea Musacchio, Director, Department of Mechanistic Cell Biology, Max-Planck Institute of Molecular Physiology .

Thursday 18 September 2014, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

From static structures to molecular movies: pushing the boundaries of X-ray Crystallography

User Wei Yang, NIH, Bethesda, USA.

Friday 05 September 2014, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The Consequences of Whole Genome Duplications

User Prof David Pellman, Professor of Cell Biology, Harvard Medical School.

Tuesday 22 July 2014, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Extrinsic regulation of haematopoietic stem cell self

User Sean J. Morrison Investigator, Howard Hughes Medical Institute.

Tuesday 15 July 2014, 11:45-13:30

House Pfizer Lecture Theatre Department of Chemistry Lensfield Road Cambridge Cambridgeshire CB2 3RA.

Interacting with Protein Interactions

"Special Event" Cambridge Cheminformatics Network Meetings

User Professor Arthur J Olson, Departmen of Interactive Structure & Computational BIology, The Scripps Research Institute, La Jolla CA.

Wednesday 09 July 2014, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Milstein Lecture 2014: Unfolded Protein Response in Health and Disease

User Peter Walter, University of California, San Francisco .

Monday 30 June 2014, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The function and execution of RTEL1 activities at vertebrate telomeres

User Dr Simon Boulton, DNA damage Response Laboratory, London Research Institute.

Friday 27 June 2014, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Exploring the final events in eukaryotic cell division

User Juan Martin-Serrano, Kings College London.

Thursday 26 June 2014, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

TBC

User Juan Martin-Serrano.

Thursday 26 June 2014, 16:15-18:00

House Unilever Lecture Theatre, Department of Chemistry.

Synergism between Theory and Experiments in Asymmetric Catalysis: Transition State Modeling for Rationalizations and Catalyst Design

User Professor Raghavan B. Sunoj, Department of Chemistry, Indian Institute of Technology, Bombay.

Thursday 19 June 2014, 14:15-15:45

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structures and mechanisms of macromolecular complexes involved in transcription and DNA repair

User Professor Xiaodong Zhang Imperial College London Department of Life Sciences.

Wednesday 11 June 2014, 10:15-11:15

House Unilever Lecture Theatre, Department of Chemistry.

"CADD & ENAC - A bad hand at Scrabble..?"

Please note that the date of this seminar has been changed

User Dr Peter Hunt, Optibrium Ltd.

Tuesday 03 June 2014, 14:15-15:45

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Crystal structure of the Drosophila Toll-Spätzle complex reveals neurotrophin-like binding specificity

User Monique Gangloff, Biochemistry.

Wednesday 28 May 2014, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Engineering strategies for tuning cell surface receptor signalling

User K. Christopher Garcia, Stanford University School of Medicine .

Wednesday 14 May 2014, 16:15-18:00

House Unilever Lecture Theatre, Department of Chemistry.

Visualization of Chemical Space for Medicinal Chemists

User Dr Peter Ertl, Novartis, Basel, Switzerland.

Tuesday 06 May 2014, 14:15-15:30

House Pfizer Lecture Theatre, Department of Chemistry.

"From fragments to target-selective ligands by reaction-driven de novo design"

User Professor Gisbert Schneider. Institute of Pharmaceutical Sciences ETH Zurich.

Monday 28 April 2014, 14:15-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structural basis of protein PARylation-dependent ubiquitination

User Rachel Klevit, University of Washington.

Thursday 24 April 2014, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Francis Crick Lecture 2014: Prions Causing Neurodegeneration: A Unifying Etiology and the Quest for Therapeutics

User Stanley Prusiner, University of California San Francisco .

Friday 11 April 2014, 15:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

What can NMR tell us about how a virus enters its host cell?

User Ad Bax, NIH.

Thursday 10 April 2014, 11:00-12:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

How insulin binds to the insulin receptor: structural biology and protein engineering

User Dr Michael Weiss, School of Medicine Cleveland, USA.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 09 April 2014, 10:15-11:15

The Structure of the Large Subunit of the Yeast Mitochondrial Ribosome

User Dr Alan Brown.

Wednesday 02 April 2014, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Building proteins de novo: better, faster, fitter

User Dek Woolfson, University of Bristol.

Thursday 27 March 2014, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Coot's EM Model-fitting Tools

User Dr Paul Emsley, MRC-LMB, Cambridge, U.K..

Wednesday 26 March 2014, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

John Kendrew Lecture 2014: Birth and Future of Multi-Scale Modeling of Macromolecules

User Michael Levitt, Standford Unversity.

Tuesday 25 March 2014, 16:15-18:00

Odorant space: From chemistry to physiology

User Dr Michael Schmuker, Neuroinformatics & Theoretical Neuroscience, Freie Universität Berlin.

Tuesday 25 March 2014, 14:15-15:45

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

microRNAs, circular RNAs, and micropeptides

User Professor Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine, Berlin.

Monday 24 March 2014, 15:00-16:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Type VI Secretion System: structure, function and dynamics of a multicomponent nanomachine that is evolutionarily related to a contractile phage tail

User Marek Basler, University of Basel.

Wednesday 26 February 2014, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Small Angle X-ray Scattering: sample preparation, data collection, and data analysis.

User Dr Meindert Lamers, MRC-LMB, Cambridge, U.K.

Wednesday 26 February 2014, 10:15-11:15

Protein-Ligand Binding by Free Energy Simulations: Issues, Successes and Failures

Please note the change of date, one week earlier than originally planned

User Professor Jonathan Essex, University of Southampton.

Tuesday 25 February 2014, 14:15-15:45

House Department of Biochemistry, Sanger building, Seminar Room.

The extracellular lysine residues of in vitro folded neuropeptide receptor type 2 interacting with its ligand observed by > NMR spectroscopy

User Dr Sandra Berndt, Nietlispach lab, Biochemistry Dept.

Wednesday 12 February 2014, 10:15-10:45

House Department of Biochemistry, Sanger building, Seminar Room.

Targeting Ubiquitin chains with Deubiquitinases

User Dr Yu Ye, Klenerman lab, Chemistry Dept.

Wednesday 12 February 2014, 10:15-10:45

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Lighting up RNA Interactions in Living Cells

User David Tollervey, WTCCB, University of Edinburgh.

Monday 10 February 2014, 14:00-15:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Cyclofluidic: Quick hit-to-lead optimization using an integrated microfluidic approach

User Dr Ronald Dorenbos, Business Development Director Europe Cyclofluidic Ltd..

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 05 February 2014, 10:15-11:15

Title to be confirmed

User Paula de Fonseca - LMB.

Tuesday 28 January 2014, 10:15-11:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Feldberg Prize Lecture: The mitochondrial machinery for transport and assembly of proteins

User Klaus Pfanner, University of Freiburg.

Thursday 23 January 2014, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Using evolutionary sequence variation to make inferences about protein structure and function

User Lucy J. Colwell, Department of Chemistry, University of Cambridge.

Wednesday 22 January 2014, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Systematic cell biology - Moving beyond text-book schemes

User Maya Schuldiner, The Weizmann Insitute of Science.

Thursday 09 January 2014, 14:00-15:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

GPCRs: From thermostabilisation to X-ray structures and Drug discovery

User Fiona Marshall, Heptares Therapeutics.

Thursday 12 December 2013, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Protein-Protein Interaction Networks and Diseases

User Franca Fraternali, Randall Division of Cell and Molecular Biophysics, King's College London, UK .

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 27 November 2013, 10:15-11:15

Analysis of allosteric communication and functional local motions using a Structural Alphabe

User Alessandro Pandini,Randall Division of Cell and Molecular Biophysics,King's College London, UK .

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 27 November 2013, 10:15-11:15

Chirality as a crossroad of chemistry and biology

User Professor Reiko KURODA, Tokyo University of Science (Japan).

Wednesday 13 November 2013, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Brain Power: Where does it come from and how is it used?

User Professor David Attwell, University College London.

Thursday 07 November 2013, 17:00-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Title to be confirmed

User Shaoxia Chen, MRC-LMB, cambridge.

Wednesday 06 November 2013, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

John Kendrew Lecture 2013: Noncoding RNAs: with a viral twist

User Joan Steitz, Yale University.

Friday 01 November 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Embracing Complexity: A Drosophila Approach To Cancer Therapeutics

User Ross Cagan, Mt. Sinai School of Medicine.

Thursday 31 October 2013, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Evolution & dynamics of protein complexes

User Sarah Teichmann, Wellcome Trust Sanger Institute.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 30 October 2013, 10:15-11:15

Crystallisation and structure of respiratory complex I, a giant molecular proton pump

User Leonid Sazanov, MRC Mitochondrial Biology Unit, Wellcome Trust / MRC Building, cambridge.

Wednesday 23 October 2013, 10:15-11:15

Protein-Ligand Binding by Free Energy Simulations: Issues, Successes and Failures

We regret that due to illness this talk has been cancelled

User Professor Jonathan Essex, University of Southampton.

Tuesday 15 October 2013, 12:00-13:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Can structural studies of intact viruses really be useful in the search for better vaccines and antivirals?

User David Stuart, University of Oxford.

Thursday 10 October 2013, 16:15-18:00

House Todd Hamied Room, Department of Chemistry.

"Global Protein Structural Analysis for Drug Discovery"

User Dr Krishna Bulusu, from the Institute of Cancer Research (ICR).

Tuesday 08 October 2013, 14:15-15:45

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Conformational Conversion in Amyloid Assembly

User Sheena Radford, University of Leeds.

Thursday 03 October 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Milstein Lecture 2013: Sorting out protein traffic: Ubiquitin-mediated endocytosis and a membrane protien’s final ESCRT

User Scott Emr, Cornell University.

Thursday 26 September 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Innate Immune Sensing and Signaling of Cytosolic DNA and RNA

User Zhijan 'James' Chen, University of Texas Southwestern Medical Center.

Tuesday 24 September 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Long-distance organelle transport in the neuron: mechanisms of motor engagement and motor coordination

User Erika Holzbaur, University of Pennyslvania.

Thursday 05 September 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The Evolutionary 'Design' of Proteins

User Rama Ranganathan, UT Southwestern Medical Centre.

Wednesday 04 September 2013, 11:00-12:00

On the importance of the COSMO polarization charge density for the quantification of molecular interactions in liquid phases

User Prof. Dr. Andreas Klamt, COSMOlogic GmbH & Co. KG.

Wednesday 28 August 2013, 15:00-16:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Watching Individual Proteins Working on Single Molecules of DNA: from Biophysics to Cancer

User Steve Kowalczykowski, University of California.

Friday 09 August 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Biological insights from cryo-EM studies of complex macromolecular assemblies in transcription initiation and microtubule dynamics

User Eva Nogales, HHMI University of California Berkely.

Wednesday 24 July 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The impact of systemic inflammation on the brain in health and disease

User Hugh Perry, University of Southampton.

Thursday 27 June 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Intrinsic biophysical diversity and connectivity of neuronal circuits

User Troy Margrie, NIMR.

Tuesday 11 June 2013, 17:00-18:00

Approaching protein dynamics in the post-genome era

User Professor Modesto Orozco, Dept. Biochemistry & Molecular Biology, University of Barcelona .

Tuesday 11 June 2013, 14:15-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Direct Selection for Antibodies that Control Cell Fates from Intracellular Combinatorial Antibody Libraries

User Professor Richard Lerner, The Scripps Research Institute, USA.

Wednesday 05 June 2013, 12:00-13:00

"Molecular Dynamics Simulations of the Influenza Virus Envelope: Complex Interplay between Membrane Proteins and Lipid Domains"

User Dr Daniel Parton, Sloan Kettering Institute, New York.

Wednesday 29 May 2013, 14:15-15:30

Calculations on Tunneling by Carbon Tell Experimentalists Where to Look and What to Look For

User Professor Wes Borden, Unversity of Texas.

Tuesday 28 May 2013, 14:15-15:30

House Pfizer Lecture Theatre, Department of Chemistry.

Why Does Cyclobutane-1,2,3,4-tetraone Have a Triplet Ground State?

A TMI RIG Presentation

User Professor Wes Borden, Unversity of Texas.

Wednesday 22 May 2013, 14:15-15:30

"Using computational methods to aid our understanding of ionotropic glutamate receptors at the molecular level"

User Dr Phil Biggin, Department of Biochemistry, University of Oxford.

Tuesday 21 May 2013, 14:15-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Cytoskeletal Control of Leukocyte Chemotaxis

User Michael Sixt, IST Austria.

Monday 13 May 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Selective autophagy: when being picky pays of

User Ana-Maria Cuervo, Albert Einstein College of Medicine .

Thursday 02 May 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Max Perutz Lecture: Five ways that viruses use to enter the animal cell

User Professor Ari Helenius, ETH Zurich, Switzerland.

Tuesday 30 April 2013, 14:30-15:30

Enzyme dynamics, conformations and catalysis

User Professor Adrian Mulholland, Centre for Computational Chemistry, Univeristy of Bristol.

Tuesday 30 April 2013, 14:15-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Machinery for making coated vesicles

User Margaret Scott Robinson, CIMR.

Tuesday 16 April 2013, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The genetics of individuals: why would a mutation kill me, but not you?

User Ben Lehner, CRG Barcelona.

Tuesday 09 April 2013, 15:00-16:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The mammalian circadian timing system: how the brain communicates with the periphery

User Ueli Schibler, University of Geneva.

Wednesday 27 March 2013, 12:00-13:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Probing dynamic conformational changes in lipid signalling using hydrogen deuterium exchangemass spectrometry

User Dr John Burke, LMB, Cambridge U.K.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 27 March 2013, 10:15-11:15

Open Source Drug Discovery: Developing a Systems Level Translational Platform for Neglected Diseases

User Prof. Samir K. Brahmachari, Founder Director, Institute of Genomics and Integrative Biology, Director General, Council of Scientific & Industrial Research, Delhi, India.

House Biochemistry Lecture Theatre, Sanger Building.

Friday 22 March 2013, 13:00-14:00

House Biochemistry Lecture Theatre, Sanger Building.

Come and meet the Monster: a work in progress on human Rad51 oligomeric structure ("the Monster") and its potential relevance for DNA Repair and drug design.

User Tommaso Moschetti (Hyvonen Group).

Tuesday 19 March 2013, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building.

Single molecule imaging reveals that CENP-A deposition occurs during G2 in fission yeast

User David Lando (Laue Group).

Tuesday 19 March 2013, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building.

New Developments at Diamond Light Source and the use of Free Electron Lasers in structural biology

User Steven Hardwick & Jarrod Voss (Luisi Group) .

Tuesday 05 March 2013, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

PHASER workshop

User Airlie McCoy, CIMR, University of Cambridge.

Wednesday 27 February 2013, 10:15-11:15

“Data Driven Molecular Design & Discovery”

User Dr Scott Lusher, Netherlands eScience Centre.

Thursday 21 February 2013, 11:00-12:00

House Biochemistry Lecture Theatre, Sanger Building.

Assembly of a protein-RNA bacterial suicide complex

User Francesca Short (Salmond Group).

Tuesday 19 February 2013, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building.

Mechanisms of extracellular regulation of TGFβ superfamily: protein engineering and interaction analysis

User Cat Donaldson (Hyvonen Group).

Tuesday 19 February 2013, 16:00-17:00

"Thinking (and looking) out of the box - new tricks for molecular simulation and visualization"

User Dr Marc Baaden, Institut de Biologie Physico-Chimque, Paris.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Tuesday 19 February 2013, 14:15-15:30

OPPF-UK: a national resource centre for protein production.

User Dr Louise Bird, OPPF, UK.

Wednesday 13 February 2013, 10:15-11:15

House Biochemistry Lecture Theatre, Sanger Building.

Snaphshots of Membrane Proteins at Work

User Simone Weyand (Lummis Group).

Tuesday 05 February 2013, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building.

The role of the acidic tail in HMGB proteins: a combined NMR and SAXS approach

User Katherine Stott (Thomas Group).

Tuesday 05 February 2013, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building.

Specificity in the Ubiquitin System

User David Komander (LMB).

Tuesday 22 January 2013, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Assembly and Dynamics of Uber Complex RNPs

User Melissa Moore, University of Massachusetts Medical School.

Monday 03 December 2012, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building.

Dissecting Fragment-Based Lead Discovery at the von Hippel Lindau protein:Hypoxia Inducible Factor-1alpha Interface

User Inge van Molle (Ciulli Group, Chemistry).

Tuesday 27 November 2012, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building.

The Discovery of Novel Sialidase Inhibitors

User Paul Brear (Hyvonen Group).

Tuesday 27 November 2012, 16:00-17:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

AnchorQuery: Interactive and efficient discovery tool of small molecule protein-protein interaction antagonists

User Carlos Carmachio.

Wednesday 21 November 2012, 10:15-11:15

House Biochemistry Lecture Theatre, Sanger Building.

Catalytic Promiscuity in the Alkaline Phosphatase Superfamily

User Bert van Loo (FH Group).

Tuesday 13 November 2012, 15:45-16:45

House Biochemistry Lecture Theatre, Sanger Building.

Label-free Study of Chromatin Architecture in Living Organisms using Stimulated Raman Scattering Microscopy

User Srinjan Basu (EDL Group).

Tuesday 13 November 2012, 15:45-16:45

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Identifying hot-spots and designing small molecule inhibitors at protein-protein interfaces: taking advantage of bound water networks

User Dr David J. Huggins, Department of Oncology Hutchison/MRC Research Centre.

Wednesday 07 November 2012, 10:15-11:15

House Biochemistry Lecture Theatre, Sanger Building.

Replication Initiation: Focus on the Components of the Pre-initiation Complex

User Oleg Kovalevskiy (Zegerman Group, Gurdon).

Tuesday 30 October 2012, 15:45-16:45

House Biochemistry Lecture Theatre, Sanger Building.

The Structural Basis of Z Alpha-1-antitrypsin Deficiency

User Tim Sendall (HM/DO Group).

Tuesday 30 October 2012, 15:45-16:45

"The mechanisms of solute flux through membrane channels from multi-microsecond equilibrium simulations"

User Dr Martin Ulmschneider, Dept. of Biological Sciences, Birkbeck College, University of London.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Tuesday 30 October 2012, 14:15-15:30

The importance of thermostability and its application to the structure determination of GPCRs

User Dr Chris Tate, LMB.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 24 October 2012, 10:15-11:15

X-ray diffraction data reduction: space group determination, scaling and intensity statistics

User Dr Phil Evans, FRS, LMB.

Wednesday 10 October 2012, 10:15-11:15

House Biochemistry Lecture Theatre, Sanger Building.

PHD Zinc Fingers in Chromatin-Associated Proteins

User Cynthia Tallant-Blanco (Cuilli Group, Chemistry).

Tuesday 09 October 2012, 15:45-16:45

House Biochemistry Lecture Theatre, Sanger Building.

NMR Applications to Large Systems: Sensory Rhodopsin II, Membrane Mimics and Fast NMR

User Mark Bostock (DN Group).

Tuesday 09 October 2012, 15:45-16:45

The Structures of Whole Chromosomes in Individual Cells

User Tim Stevens (EDL Group).

Tuesday 18 September 2012, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

New insights into the role of the chromatin associated factor ATRX

User Doug Higgs, MRC Molecular Haematology Unit, Oxford.

Monday 17 September 2012, 11:30-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Max Perutz Lecture 2012: Defective DNA strand break repair, genome instability and cancer

User Steve West, CRUK LRI - Clare Hall.

Thursday 13 September 2012, 16:15-18:00

House Cambridge Research Institute.

Lgr5 Stem Cells in self-renewal and cancer

Joint lecture with CRI and MRC LMB

User Hans Clevers, Hubrecht Institute.

Tuesday 11 September 2012, 13:00-14:30

Successes and challenges in the prediction of P450 mediated drug metabolism

User Professor Patrik Rydberg, University of Copenhagen, Department of Drug Design and Pharmacology.

Tuesday 04 September 2012, 14:00-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Normal and neoplastic stem cells

User Irving Weissman, Stanford School of Medicine.

Wednesday 11 July 2012, 16:15-18:00

"Entropy and order parameters from ensembles generated by computer simulations"

User Profressor Klaus Liedl, University of Innsbruck.

Wednesday 27 June 2012, 15:15-16:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Mechanisms for the Selective Degradation of Ubiquitinated Proteins by the 26S Proteasome

User Fred Goldberg, Harvard Medical School.

Friday 22 June 2012, 16:15-18:00

House Pfizer Lecture Theatre, Dept. of Chemistry.

"Dynamics of Biomolecules: from the Glass Transition to Drug Design"

A joint Theory/UCC talk as part of the TMI Research Interest Group

User Professor Jeremy C Smith, Oak Ridge National Laboratory.

Wednesday 20 June 2012, 14:15-15:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Title to be confirmed

User Helen Saibil.

Wednesday 13 June 2012, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Shedding light on Ubiquitin Modification in Cancer.

User Vishva Dixit, Genentech.

Tuesday 12 June 2012, 16:15-18:00

Crystal Structure of Folliculin Uncovers a HiDENN Function

User Ravi Nookala (TLB Group).

Tuesday 12 June 2012, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The structural and mechanistic basis for Rab cycling and targeting

User Roger Goody, MPI Dortmund.

Monday 21 May 2012, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Milstein Lecture 2012: How do we sense microbes? From LPS, TNF, and the TLRs.

User Bruce Beutler, UT Southwestern Medical Centre.

Thursday 17 May 2012, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Monitoring protein synthesis one codon at a time through ribosome profiling

User Jonathan Weissman, Howard Hughes Medical Institute, UCSF.

Thursday 10 May 2012, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Structural studies of chromosome segregation

User Martin Singleton.

Wednesday 02 May 2012, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Local Translation at the Synapse

User Erin Schuman, Max Planck Institute.

Monday 30 April 2012, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

How end binding proteins recognise growing microtubule ends: from molecular structure to network functioning

User Thomas Surrey, Cancer Research UK, London Research Institute.

Thursday 26 April 2012, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

SAXS studies on biological molecules at Diamond Light Source

User Inoue Katsuaki, DLS, UK.

Wednesday 25 April 2012, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Molecular mechanisms of complement activation and regulation

User Piet Gros, Utrecht University.

Thursday 19 April 2012, 14:00-16:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Ubiquitin flips the anaphase switch

User David Morgan, UCSF.

Friday 13 April 2012, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

John Kendrew Lecture 2012: Harnessing actin dynamics for endocytic trafficking events

User David Drubin, Berkeley.

Tuesday 03 April 2012, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building.

Structural studies of HAT1 and its binding partners

User Ian Le Guillou (EDL).

Tuesday 20 March 2012, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building.

Allosteric Regulation and Assembly of Glutamate Receptor Ion Channels.

User Maxim Rossmann (MH).

Tuesday 20 March 2012, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building.

David Lando Talk

User David Lando (Laue Group).

Monday 19 March 2012, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

A Chemicogenetic approach to DNA repair implicates TORC2 and actin in survival of DNA breaks

User Susan Gasser, Friedrich Miescher Institute for Biomedical Research.

Monday 12 March 2012, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Disruptions on the Highways of Cell Communication

User Dario Alessi, MRC Protein Phosphorylation Unit, University of Dundee.

Tuesday 06 March 2012, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building.

From protein interactions to gene expression distributions

User Sarah Teichmann (LMB).

Tuesday 06 March 2012, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structural and Biochemical Mechanisms of Synchronous Synaptic Transmission

User James Rothman, Yale University.

Tuesday 21 February 2012, 11:30-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Crick Lecture 2012: Consequences of Aneuploidy

User Angelika Amon, HHMI, MIT.

Wednesday 15 February 2012, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building.

Solid-State NMR Investigations of Membrane Bound Ras Proteins and Y2 G Protein-Coupled Receptors

User Prof. Daniel Huster. Institute for Medical Physics and Biophysics, University of Leipzig.

Tuesday 14 February 2012, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

New concepts in host-pathogen interactions: lessons from Listeria

User Pascale Cossart, Institute Pasteur, Paris.

Thursday 02 February 2012, 16:15-18:00

Lessons from Yeast: Drug Uptake and Systems Biology

User Dr Paul D Dobson, Department of Chemical & Biological Engineering, University of Sheffield.

Tuesday 31 January 2012, 14:00-15:30

House Biochemistry Lecture Theatre, Sanger Building.

Structural Biology facilities - Updates and Discussion Session

User Dima Chirgadze, Katherine Stott.

Tuesday 24 January 2012, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Functions of Dynamin A, Myosin IB and WASH in phagolysosome biogenesis, and the Exocyst in kiss-and-run exocytosis in Dictyostelium

User Thierry Soldati, University of Geneva.

Monday 23 January 2012, 16:15-18:00

A Study of the Human Primase: Initiator of DNA Replication

User Mairi Kilkenny (LP).

Tuesday 10 January 2012, 16:00-17:00

Relating structure to function in natural surfactant proteins.

User Steve Vance (RWB).

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Tuesday 10 January 2012, 16:00-17:00

Domain swapping in proteins

User Dr Sowdhamini, National Centre for Biological Sciences (TIFR) UAS-GKVK Campus Bellary Road Bangalore 560 065 INDIA.

Wednesday 21 December 2011, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Signaling through the ubiquitin system

User Wade Harper, Harvard Medical School.

Thursday 15 December 2011, 16:15-18:00

Journal Club

User Heather (BL).

Monday 12 December 2011, 10:55-11:15

Journal Club

User Angela (TLB).

Monday 12 December 2011, 10:35-10:55

Journal Club

User Sandra (MH).

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Monday 12 December 2011, 10:15-10:35

To be confirmed

User Dr Bissan Al-Lazikani, Computational Biology and Chemogenomics Institute of Cancer Research, U.K.

Wednesday 07 December 2011, 10:15-11:15

FKBP - a structure without a cause?

User Christian Edlich (EDL).

Tuesday 06 December 2011, 16:00-17:00

Model interaction systems in the search for inhibitors of protein-protein interactions

User Sandra Greive (MH).

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Tuesday 06 December 2011, 16:00-17:00

Low Resolution Crystallography

User Dr Dima Chirgadze, Biochemistry Department, University of Cambridge.

Wednesday 30 November 2011, 10:15-11:15

House Biochemistry Lecture Theatre, Sanger Building.

Zinc fingers reading signals

User David Neuhaus (LMB).

Tuesday 29 November 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structural and Mechanistic Studies of the Anaphase Promoting Complex

User David Barford, Institute of Cancer Research.

Thursday 24 November 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Making candy for signal transduction research - Adventures in Willy Wonka land

User Prof Morten Grötli, Department of Chemistry, University of Gothenburg.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Thursday 24 November 2011, 11:00-12:00

Low resolution refinement tools in the program REFMAC

User Dr Garib N Murshudov, LMB, MRC, Cambridge, U.K.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 23 November 2011, 10:15-11:15

Fuzzy complexes: ambiguity in protein-protein and protein-DNA interactions

User Professor Monika Fuxreiter Institute of Enzymology, Budapest, HUNGARY and LMB, MRC, Cambridge, UK.

Wednesday 16 November 2011, 10:15-11:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The Evolution of Enzyme Mechanisms and Functional Diversity

User Janet Thornton, EMBL-EBI.

Tuesday 15 November 2011, 16:15-18:00

House Biochemistry Lecture Theatre, Sanger Building.

A Bayesian view on cryo-EM structure determination

User Sjors Scheres (LMB).

Tuesday 15 November 2011, 16:00-17:00

Journal Club

User Cat (MH).

Monday 14 November 2011, 10:55-11:15

Journal Club

User Steven (BL).

Monday 14 November 2011, 10:35-10:55

Journal Club

User Ravi (TLB).

Monday 14 November 2011, 10:15-10:35

House Biochemistry Lecture Theatre, Sanger Building.

Structural and interaction studies of domain C0 of cardiac Myosin Binding Protein C (cMyBP-C) by NMR spectroscopy

User Joyce Ratti (NM).

Tuesday 01 November 2011, 16:00-17:00

House Biochemistry Lecture Theatre, Sanger Building.

At the Frontier of Membrane Protein Crystallography: The Structure of Yeast Aquaporin to 0.9 Å at Cryogenic and 1.3 Å at Room Temperature.

User Gerhard Fischer (University of Gothenburg, Sweden).

Tuesday 01 November 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structural Studies on the Regulation of Protein Kinases: EGFR and CamK-II

User John Kuriyan, HHMI, University of California, Berkeley.

Monday 31 October 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Neuronal plasticity: from synapses to the axon initial segment

User Juan Burrone, Kings College London.

Friday 28 October 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

DNA-dependent protein kinase is a DNA sensor for IRF-3-dependent innate immunity

User Geoffrey Smith, Department of Pathology Cambridge.

Thursday 06 October 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

mRNA-tRNA translocation intermediates by cryo-EM: a look at the free-energy landscape from a single sample.

User Joachim Frank, Columbia University.

Friday 30 September 2011, 16:15-18:00

House Pfizer Lecture Theatre, Dept. of Chemistry.

"New Developments in Semiempirical MO Theory for Drug and Materials Design"

This Lecture is part of Professor Clark's MGMS Lecture tour

User Professor Tim Clark, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.

Thursday 22 September 2011, 14:00-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Molecular and cellular mechanisms for memory allocation in neuronal networks

User Alcino Silva, UCLA.

Friday 16 September 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Genetic dissection of emotion circuits in flies and mice - Francis Crick Lecture 2011

User Dr David Anderson, California Institute of Technology, USA.

Friday 09 September 2011, 16:00-18:00

Most recent development in crystalisation optimization and shotgun diffraction

User Professor Seth Fraden, Brandeis University,Waltham, MA, USA.

Friday 29 July 2011, 14:00-15:00

Snapshots of the membrane protein Mhp1 at work

User Dr Simone Weyand, Imperial College.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Friday 29 July 2011, 12:00-13:00

Structural complexomics of eukaryotic gene expression.

User Dr Imre Berger, EMBL, Grenoble, France.

Wednesday 27 July 2011, 10:15-11:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Self-assembled DNA-nanostructure tools for molecular biophysics

User William Shih, Harvard Medical School.

Monday 25 July 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

PDBe - Bringing Structure to Biology

User Gerard Kleywegt, EMBL-EBI.

Thursday 14 July 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Receptor-based Drug Discovery

User Dr Jiye Shi, UCB Celltech.

Wednesday 13 July 2011, 10:15-11:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Tuberculosis Treatment Dicta from the Zebrafish

User Lalita Ramakrishnan, University of Washington.

Thursday 07 July 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Probing protein-ligand recognition mechanisms with isothermal titration calorimetry

User Dr Mark Williams. Birkbeck College.

House Room 2, Stem Cell Research Centre.

Wednesday 06 July 2011, 11:00-12:00

"Structural Basis of the Regulation of Chromosome Segregation and Mitosis Progression"

User Victor Bolanos-Garcia (TLB group).

Tuesday 28 June 2011, 16:00-17:00

"A new structural genomics: the structures of whole chromosomes"

User Tim Stevens (EDL).

Tuesday 28 June 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Autoantibodies against NMDA receptors and other neuronal targets: the widening spectrum of antibody-mediated CNS disorders

User Angela Vincent, University of Oxford.

Wednesday 22 June 2011, 14:30-16:15

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Crystal dehydration: Experimental design with a home source and at the synchroton

User Dr Juan Sanchez Weatherby: Diamond, UK.

Wednesday 22 June 2011, 10:15-11:00

"Structure of a motor-driven restriction-modification enzyme bound to its target DNA"

User Saikrishnan Kayarat (LMB).

Tuesday 21 June 2011, 16:00-17:00

"Structure-function studies of the archaeal HR nuclease NurA"

User Neil Rzechorzek (LP group).

Tuesday 21 June 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Exploring and exploiting chromosome repair and segregation mechanisms in cancer

User Ashok Venkitaraman, MRC Cancer Cell Unit.

Thursday 16 June 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Designing Bioactive Molecules and Mode-of-Action Analyses - The Benefits of Learning From the Past.

User Dr Andreas Bender, Unilever Centre, Cambridge.

Wednesday 15 June 2011, 10:15-11:00

Determining structures with NMR - the CcpNmr Analysis program

User Rasmus Fogh (EDL Group).

Tuesday 07 June 2011, 16:00-17:00

"DNA Polymerase alpha at work: Understanding the Mechanism"

User Rajika Perera (LP group).

Tuesday 07 June 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Visualizing vesicle and virus budding by electron microscopy

User John Briggs, EMBL.

Wednesday 01 June 2011, 11:30-13:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Genetic Architecture of Leukaemia

User Mel Greaves, Institute of Cancer Research.

Thursday 19 May 2011, 16:15-18:00

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Exploring free-energy landscapes

User Professor Daan Frenkel FRS, Cambridge University Centre for Computational Chemistry, Department of Chemistry.

Thursday 19 May 2011, 15:30-16:30

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

The power of coarse-graining in biomolecular simulations

User Professor Siewert-Jan Marrink, Groningen Biomolecular Sciences and Biotechnology Institute.

Thursday 19 May 2011, 14:00-15:30

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

"Manipulating dynamics: Galilean-invariant friction and stochastic thermostats"

User Professor Herman Berendsen, Groningen Biomolecular Sciences and Biotechnology Institute.

Wednesday 18 May 2011, 14:00-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Delivery Boy to Reporter: Unusual DNA’s journey through a worm-whole

User Yamuna Krishnan, National Centre for Biological Sciences Bangalore.

Tuesday 17 May 2011, 16:15-18:00

"Chromatin Assembly Factor 1: Working with protein complexes"

User Nikki Royle (EDL group).

Tuesday 17 May 2011, 16:00-17:00

"Structural studies of non-coding RNA mediated gene silencing in E. coli"

User Kasia Bandyra (BL group).

Tuesday 17 May 2011, 16:00-17:00

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

"Molecular dynamics beyond molecules: principles for coarse-graining"

User Professor Herman Berendsen, Groningen Biomolecular Sciences and Biotechnology Institute.

Tuesday 17 May 2011, 14:00-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

A primer on DNA origami and why molecular biologists might care

User Hendrik Dietz, TU Munich.

Thursday 12 May 2011, 16:15-18:00

"Mimicking the membrane; micelles, bicelles and nanodiscs"

User Mark Bostock (DN group).

Tuesday 10 May 2011, 16:00-17:00

"Do very similar proteins fold in very similar ways?"

User Tim Sharpe (MH group).

Tuesday 10 May 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Genome-wide analysis of AID activity and AID-mediated translocations in B lymphocytes

User Rafael Casellas, NIH.

Friday 06 May 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Feldberg Prize Lecture: Biogenesis of iron-sulfur proteins in eukaryotes

User Professor Roland Lill, Philipps University Marburg, Germany.

Friday 15 April 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Controlling Recombination

User Simon Boulton, CRUK Clare Hall Laboratories.

Thursday 14 April 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae

User Anne-Claude Gavin, EMBL.

Tuesday 12 April 2011, 16:15-18:00

"Using high throughput simulation to understand signalling processes"

User Benjamin Hall (University of Oxford).

Tuesday 12 April 2011, 16:00-17:00

"Structure of RLIP76’s GTPase activating (GAP) and Ral binding domains (RBD) in solution"

User Karthik Rajasekar (HRM-DO group).

Tuesday 12 April 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Milstein Lecture 2011: How the endoplasmic reticulum gets into shape

User Tom Rapoport, Harvard Medical School.

Thursday 07 April 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The Chemical Biology of Large-Scale Transcriptome Analysis

User Kevin Weeks, University of North Carolina.

Wednesday 06 April 2011, 11:30-13:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The Cellular Basis for the Cancer-Related Phenomena of Immune Suppression and Cachexia

User Doug Fearon.

Thursday 31 March 2011, 16:15-18:00

"Super-resolution imaging in pombe"

User David Lando (EDL Group).

Tuesday 29 March 2011, 16:00-17:00

"Structural studies of a human non-homologous end-joing protein complex: DNA ligaseIV/XRCC4"

User Takashi Ochi (TLB group).

Tuesday 29 March 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The Female Side of Fertilization: Crystal Structure of Vertebrate Sperm Receptor ZP3

User Luca Jovine, Karolinska Institute.

Monday 28 March 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The Structural Basis of Ubiquitin Signalling

User Cynthia Wolberger, Johns Hopkins University.

Friday 25 March 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Repeat Proteins:Versatile frameworks for understanding and engineering protein structure and function

User Lynne Regan, Yale University.

Monday 21 March 2011, 16:15-18:00

Journal Club

User Daniela (BL).

Monday 21 March 2011, 10:55-11:15

Journal Club

User May (MH).

Monday 21 March 2011, 10:35-10:55

Journal Club

User Kasia (BL).

Monday 21 March 2011, 10:15-10:35

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Non-classical means for regulating small G-proteins

User Shehab Ismail, Max Planck Institute Dortmund.

Thursday 17 March 2011, 16:15-18:00

"Segmental labelling approaches for multi-domain proteins"

User Bill Broadhurst (RWB group).

Tuesday 15 March 2011, 16:00-17:00

"New dimensions in the study of protein complexes using mass spectrometry"

User Dijana Matak-Vinkovic (Dept. Chemistry).

Tuesday 15 March 2011, 16:00-17:00

"The structural studies of PHD+CXXC domain"

User Buyu Li (EDL group).

Tuesday 08 March 2011, 16:00-17:00

"Fragment-based drug discovery on the MET receptor"

User Anja Winter (TLB group).

Tuesday 08 March 2011, 16:00-17:00

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

"Bioactivity Mapping of Chemical Space"

User Dr Jordi Mestres, IMIM, Barcelona Biomedical Reseach Park.

Tuesday 08 March 2011, 14:15-15:30

Journal Club

User Takashi (TLB).

Monday 28 February 2011, 10:55-11:15

Journal Club

User Sachin (TLB).

Monday 28 February 2011, 10:35-10:55

Journal Club

User Alicia (TLB).

Monday 28 February 2011, 10:15-10:35

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Neurotransmitter transporters: from ligand-based to systems chemical biology approaches

User Professor Olivier Taboureau, Center for Biological Sequence Analysis, Technical University of Denmark.

Tuesday 22 February 2011, 14:15-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Accuracy of codon reading by transfer RNAs

User Måns Ehrenberg.

Friday 18 February 2011, 11:30-13:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Transport mechanism and membrane interactions of the cation pumps

User Poul Nissen, Aarhus University, Denmark.

Thursday 17 February 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Pre- and postsynaptic NMDA receptors in neocortical synaptic plasticity

User Ole Paulsen, Department of Physiology, University of Cambridge.

Tuesday 15 February 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Transcription and R-loops as a source of genome instability

User Andrés Aguilera, University of Seville.

Tuesday 08 February 2011, 16:15-18:00

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Toxicity from Predicting Chemistry - Categories, Read-Across and Integrated Testing Strategies

User Professor Mark Cronin, Liverpool John Moores University.

Tuesday 08 February 2011, 14:15-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

In vitro and in vivo single molecule studies of chromosome replication and segregation

User David Sherratt, University of Oxford.

Monday 07 February 2011, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Genetic approaches to understand and manipulate retinal circuit function

User Botond Roska, Friedrich Miescher Institute for Biomedical Research.

Thursday 03 February 2011, 16:15-18:00

Super-resolution imaging in pombe

User David Lando (EDL group).

Tuesday 01 February 2011, 16:00-17:00

"Structural Studies Of Innate Immune Response"

User Eugene Valkov (MH group).

Tuesday 01 February 2011, 16:00-17:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Off-the-shelf models of chromosomal translocations and using antibody fragments as cancer drug surrogates

User Terry Rabbitts, Leeds Institute of Molecular Medicine.

Monday 31 January 2011, 16:15-18:00

Journal Club

User Sandra (MH).

Monday 31 January 2011, 10:55-11:15

Journal Club

User Jarrod (BL).

Monday 31 January 2011, 10:35-10:55

Journal Club

User Xue (BL).

Monday 31 January 2011, 10:15-10:35

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Crystal structures of bacterial and yeast ribosomes

User Marat Yusupov, Illkirch, France.

Thursday 27 January 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Drug Protein Interaction Databases

User Adrian Schreyer, Alicia Higueruelo, Will Pitt.

Wednesday 26 January 2011, 10:15-11:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Interactions of Cancer Stem Cells with their Niches are Essential for Breast Cancer Metastasis

User Dr Joerg Huelsken, Swiss Federal Univerity of Technology, Lausanne, Switzerland.

Tuesday 25 January 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The Ghosts of PDBe Past, Present and Yet to Come

User Dr Gerard Kleywegt, PDB Europe, EBI, Hinxton.

Wednesday 12 January 2011, 10:15-11:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

The mechanism of retroviral DNA integration through X-ray structures of its key intermediates

User Peter Cherepanov, Faculty of Medicine, Imperial College.

Tuesday 11 January 2011, 16:15-18:00

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

i-SITE: An energetic approach to predict ligand-binding site on protein surface

User Dr Mizuki Morita, Laboratory of Bioinformatics, National Institute of Biomedical Innovation (NIBIO), Japan.

Monday 10 January 2011, 11:30-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structural biology of bacterial secretion systems

User Gabriel Waksman.

Monday 13 December 2010, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Protein folding homeostasis and prion-like propagation of protein aggregation in neurodegenerative disease

User Ron Kopito, Stanford University, CA USA.

Friday 10 December 2010, 14:15-16:00

Modular Protein Architecture, Cooperativity and Complexity in Cell Regulation

User Speaker to be confirmed.

Friday 10 December 2010, 12:00-13:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Structural insights into the process of co-translational targeting of membrane proteins and translation initiation in eukaryotes

User Nenad Ban.

Monday 06 December 2010, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Femtosecond Membrane-Protein Nanodiffraction using a Hard X-Ray Laser

User John Spence, Arizona State University.

Tuesday 23 November 2010, 16:15-18:00

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

"Visualising and Predicting Organic Reactivity"

User Dr Scott L Cockroft, Lecturer in Organic Chemistry, University of Edinburgh.

Tuesday 23 November 2010, 14:15-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Dehydrated but unharmed? – the mass spectrometry of protein complexes

User Professor Carol Robinson, Department of Chemistry, Oxford University.

Monday 22 November 2010, 16:15-18:00

Journal Club

User Alicia (TLB).

Monday 22 November 2010, 10:55-11:15

Journal Club

User Anja (TLB).

Monday 22 November 2010, 10:35-10:55

Journal Club

User Zbyszek (BL).

Monday 22 November 2010, 10:15-10:35

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Deconstructin oncogenesis and tumour suppression to find the best cancer drug targets

User Gerard Evan, Department of Biochemistry, Unversity of Cambridge.

Thursday 18 November 2010, 16:15-18:00

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

“Accurate in-silico predictions can halve costs for experimental ADME Tox studies”

User Dr Igor Tetko, Institute for Bioinformatics & Systems Biology, Neuherberg.

Tuesday 16 November 2010, 14:15-15:15

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Regulation of microRNA biogenesis and function

User Javier F Caceres, MRC Human Genetics Unit, Edinburgh.

Monday 15 November 2010, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Nucleocytoplasmic Transport Machinery and Pathways: Cell Cycle Regulation and Stress Response

User Naoko Imamoto, Cellular Dynamics Laboratory, RIKEN ASI.

Monday 15 November 2010, 14:00-16:00

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

'“Multi-Scale Methods for the Investigation of Biological Structures and Processes”

User Professor Marcus Elstner, Karlsruhe Institute of Technology.

Tuesday 09 November 2010, 14:15-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Mitosis and Meiosis in live mammalian cells: From genome wide RNAi profiling to homologous chromosome segregation

User Jan Ellenberg, EMBL, Heidelberg, Germany.

Friday 05 November 2010, 14:15-16:00

Journal Club

User Will (TLB).

Monday 01 November 2010, 10:55-11:15

Journal Club

User Michal (TLB).

Monday 01 November 2010, 10:35-10:55

Journal Club

User Tim (MH).

Monday 01 November 2010, 10:15-10:35

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Exploring chemico-biological interactions using connectivity mapping

User Dr Timothy Gant, MRC Toxicology Unit, University of Leicester.

Tuesday 26 October 2010, 14:15-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Ion channels: Structure, modulation, and unconventional approaches

User Dan Minor, University of California, San Francisco, USA.

Monday 25 October 2010, 16:15-18:00

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

The bacterial outer membrane: capturing the details with molecular dynamics simulations

User Dr Syma Khalid, School of Chemistry, University of Southampton.

Tuesday 19 October 2010, 14:15-15:30

House Todd Hamied Room, Dept. of Chemistry.

Application of Informatics within Unilever

User Dr Ian Stott, Informatics & Maths Leader, Unilever R & D, Port Sunlight.

Wednesday 13 October 2010, 14:15-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Role of intrinsic Flexibility in Protein Regulatory Mechanisms

User Richard Kriwacki, St Jude's Children's Research Hospital, USA.

Thursday 07 October 2010, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Small Molecules and Light as Tools for the Regulation of Biological Proceeses

User Alex Deiters, North Carolina State University, USA.

Wednesday 29 September 2010, 16:15-18:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Connecting transcription with mRNA processing and chromatin

User Steve Buratowski Harvard Medical School, USA.

Tuesday 21 September 2010, 16:15-18:00

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Past, present, and future of semiempirical methods

User Dr James J P Stewart, Stewart Computational Chemistry, Colorado Springs, USA.

Thursday 16 September 2010, 14:15-15:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Autophagy: molecular machinery and role in diseases

User Tamotsu Yoshimori Osaka University, Japan.

Monday 13 September 2010, 12:15-13:30

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Gene Regulatory Network Guidance of Cellular Identity Choice: Stem Cells to T Cell

User Ellen Rothenberg California Institute of Technology, USA.

Monday 13 September 2010, 11:00-12:00

House Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

Assembly and function of K11-linked ubiquitin chains

User Michael Rape, University of California, Berkeley, USA.

Wednesday 08 September 2010, 11:15-13:30

House Unilever Lecture Theatre, Unilever Centre for Molecular Informatics, Dept. of Chemistry.

Challenges in rational computer aided enzyme design

User Professor Arieh Warshe, University of Southern California.

Thursday 02 September 2010, 14:15-15:30

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

The rational design of small-molecule Neuropilin-1 antagonists

User Trevor Perrior, Research Director of Domainex.

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 14 July 2010, 10:15-11:00

Restraints on Protein Models from NMR Chemical Shifts

User Rinaldo Wander Montalvao (Chemistry, Cambridge)..

Experimental and Computational Aspects of Structural Biology and Applications to Drug Discovery

Wednesday 07 July 2010, 10:35-11:00

Software for fragment linking and growing.

User Nikolay Todorov (Molscape).

Wednesday 07 July 2010, 10:15-11:00

Journal Club

User Anja (TLB).

Monday 05 July 2010, 10:55-11:15

Journal Club

User Marcio (TLB).